Kawasaki disease: a review with emphasis on cardiovascular complications.
Kawasaki disease: a review with emphasis on cardiovascular complications.
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DOI：
10.1007/s13244-010-0035-6
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发表时间：
2010-09
影响因子：
4.7
通讯作者：
Apocada, Asier
中科院分区：
文献类型：
--
作者：
Duarte, Ricardo;Cisneros, Silvia;Fernandez, Gabriel;Castellon, Daniel;Cattani, Cesar;A Melo, Cintia;Apocada, Asier
川崎病(KD)是一种急性系统性脉管炎，目前是美国儿童获得性心脏病的主要原因。心血管并发症是发病率的主要原因，是KD几乎所有死亡的罪魁祸首，应在急性期后尽快进行评估，以确定基线状态，以便预测疾病进展并确定适当的治疗。在选定的患者中，心电门控心脏计算机断层扫描(CT)和磁共振(MR)成像是有价值的非侵入性技术，可用于帮助诊断与KD相关的心血管并发症。本文就KD的流行病学、病原学和发病机制、组织病理学、临床特点、心血管并发症和影像学作一综述，重点介绍心脏CT和MR在KD心血管并发症的初步评估和随访中的作用。
Kawasaki disease (KD) is an acute systemic vasculitis that is currently the leading cause of acquired heart disease in childhood in the United States. Cardiovascular complications are the major cause of morbidity, are responsible for virtually all deaths from KD and should be evaluated as soon as possible after the acute phase to establish the baseline status, in order to predict disease progression and determine adequate treatment. In selected patients, electrocardiography (ECG)-gated cardiac computed tomography (CT) and magnetic resonance (MR) imaging are valuable non-invasive techniques that can be used to help diagnose the cardiovascular complications associated with KD. In this article, we review the epidemiology, aetiology and pathogenesis, histopathology, clinical features, cardiovascular complications and imaging, focusing on the role of cardiac CT and MR on the initial assessment and follow-up of the cardiovascular complications of KD.