In vivo glucose measurement by surface-enhanced Raman spectroscopy
In vivo glucose measurement by surface-enhanced Raman spectroscopy
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DOI：
10.1021/ac061238u
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发表时间：
2006-10-15
影响因子：
7.4
通讯作者：
Van Duyne, Richard P.
中科院分区：
文献类型：
--
作者：
Stuart, Douglas A.;Yuen, Jonathan M.;Van Duyne, Richard P.
本文介绍了表面增强拉曼散射(SERS)在体内的首次应用。SERS被用来从动物模型中获得体内血糖的定量测量。用双组分自组装单分子膜对纳米球表面的银膜进行功能化处理，并将其植入SD大鼠的皮下，通过光学窗口对传感器进行光谱寻址，从而测量间质液体中的葡萄糖浓度。该传感器具有较低的误差(RMSEC=7.46 mg/dL(0.41 mm)，RMSEP=53.42 mg/dL(2.97 mm))。
This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).