A SEVERE OUTBREAK OF HEMORRHAGIC COLITIS AND HEMOLYTIC SYNDROME-ASSOCIATED WITH ESCHERICHIA-COLI O157-H7 IN JAPAN
A SEVERE OUTBREAK OF HEMORRHAGIC COLITIS AND HEMOLYTIC SYNDROME-ASSOCIATED WITH ESCHERICHIA-COLI O157-H7 IN JAPAN
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DOI：
10.1007/s004310050206
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发表时间：
1994-09-01
影响因子：
3.6
通讯作者：
NAKAMURA, T
中科院分区：
文献类型：
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作者：
AKASHI, S;JOH, K;NAKAMURA, T
1990年，日本琦玉市一所幼儿园的174名儿童中爆发了大肠杆菌O 157：H7感染。该生物体是从学校水井供应的自来水中分离出来的。临床表现从无症状感染到非出血性腹泻、出血性结肠炎、溶血性尿毒综合征（HUS）和死亡不等。培养证实的42例大肠杆菌中，大肠杆菌O157：H7感染，7例无症状，21例仅腹泻，14例发生溶血尿毒综合征。最初频繁腹泻后的血性腹泻伴腹痛似乎与随后的HUS相关。在HUS患者中，白细胞计数和乳酸脱氢酶活性在疾病的早期阶段持续增加，并且在疾病的第3天达到比没有HUS的患者明显更高的水平。这两个参数似乎是重要的发展HUS的预测。
In 1990, an outbreak of Escherichia coli O157:H7 infection occurred in 174 children in a nursery school in Saitama, Japan. The organism was isolated from tap water supplied from the well in the school. Clinical manifestations varied from asymptomatic infection to nonbloody diarrhoea, haemorrhagic colitis, haemolytic uraemic syndrome (HUS) and death. Among culture-confirmed 42 cases of E. coli O157:H7, 7 children were asymptomatic, 21 children had only diarrhoea, and 14 children developed HUS. Bloody diarrhoea with abdominal pain following initial frequent diarrhoea appeared to be associated with subsequent HUS. In patients with HUS, both leucocyte count and lactate dehydrogenase activity continued to increase in the early phase of the disease, and on day 3 of illness attained markedly higher levels than in patients without HUS. These two parameters seemed to be important as predictors of the development of HUS.