Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment
Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment
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DOI：
10.1183/09031936.03.00010103
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发表时间：
2003-08-01
影响因子：
24.3
通讯作者：
Ficker, JH
中科院分区：
文献类型：
--
作者：
Harsch, IA;Konturek, PC;Ficker, JH
研究阻塞性睡眠呼吸暂停综合征（OSA）患者在持续气道正压通气（CPAP）治疗前和治疗中血清瘦素和生长素释放肽水平，并与体重指数（BMI）匹配的无OSA对照组进行比较。在基线和2天时测量空腹瘦素和ghrelin，在开始治疗2个月后测量瘦素。OSA患者的基线血浆ghrelin水平显著高于对照组。CPAP治疗2天后，几乎所有OSA患者（n=9）的血浆ghrelin水平均下降至仅略高于对照组（n=9）。CPAP治疗2天后，瘦素水平与基线相比没有显著变化，但高于对照组。8周后，瘦素水平显著下降，尽管患者的BMI没有变化。瘦素水平的下降在BMI
Serum leptin and ghrelin levels were investigated in patients with obstructive sleep apnoea (OSA) syndrome before and during continuous positive airways pressure (CPAP) treatment and compared with body mass index (BMI)-matched controls without OSA.Male patients (n=30) with OSA (apnoea/hypopnoea index=58+/-16, BMI=32.6+/-5.3 kg.m(-2)) underwent CPAP treatment. Fasting leptin and ghrelin were measured at baseline and 2 days, and in the case of leptin 2 months after initiation of treatment.Baseline plasma ghrelin levels were significantly higher in OSA patients than in controls. After 2 days of CPAP treatment, plasma ghrelin decreased in almost all OSA patients (n=9) to levels that were only slightly higher than those of controls (n=9). Leptin levels did not change significantly from baseline after 2 days of CPAP treatment, but were higher than in the control group. After 8 weeks, leptin levels decreased significantly, although the BMI of the patients showed no change. The decrease in leptin levels was more pronounced in patients with a BMI