Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs
Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs
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DOI：
10.1080/00016480801891694
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发表时间：
2008-01-01
影响因子：
1.4
通讯作者：
Yamashita, Hiroshi
中科院分区：
文献类型：
--
作者：
Hirose, Yoshinobu;Sugahara, Kazuma;Yamashita, Hiroshi
结论。本研究结果表明，辅酶Q10可减轻声过度刺激所致的耳蜗氧化应激。目标。我们研究了辅酶Q10对噪声性听力损失的影响。材料和方法。噪声暴露前2小时，动物经腹腔注射水溶性辅酶Q10。噪声暴露后7d(130dB声压级，3h)，检测听性脑干反应(ABR)阈值漂移和耳蜗毛细胞损伤。结果。我们观察到辅酶Q10组的ABR阈值漂移明显小于赋形剂对照组。此外，辅酶Q10组缺失外毛细胞的百分比低于对照组。此外，在给药2天后，通过电子自旋共振对羟基自由基清除活性的分析，观察到耳蜗中的抗氧化活性增加。
Conclusion. The results of this study indicate that coenzyme Q10 reduces cochlear oxidative stress induced by acoustic overstimulation. Objective. We investigated the effects of coenzyme Q10 on noise-induced hearing loss in guinea pigs. Materials and methods. Animals received water-soluble coenzyme Q10 intraperitoneally 2 h before noise exposure. Seven days after noise exposure (130 dB sound pressure level for 3 h), the auditory brainstem response (ABR) threshold shift and cochlear hair cell damage were assessed. Results. We observed that the ABR threshold shift was significantly less in the coenzyme Q10 group than in the vehicle control group. In addition, the percentage of missing outer hair cells was lower in the coenzyme Q10 group than in the control group. Moreover, 2 days after administration of coenzyme Q10, increased antioxidative activity in the cochlea, as measured by analysis of hydroxy radical scavenging activity by electron spin resonance was observed.