Working memory capacity predicts dopamine synthesis capacity in the human striatum
Working memory capacity predicts dopamine synthesis capacity in the human striatum
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DOI：
10.1523/jneurosci.4475-07.2008
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发表时间：
2008-01-30
影响因子：
5.3
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
--
作者：
Cools, Roshan;Gibbs, Sasha E.;D'Esposito, Mark
精神药理学研究的证据表明，多巴胺受体药物对认知功能具有相反的影响，具体取决于工作记忆能力的基线水平。这些对比效应被解释为反映多巴胺基线水平的差异。在这里，我们首次证明，通过听力跨度测量的工作记忆容量可以预测纹状体中的多巴胺合成能力，表明工作记忆容量低的受试者纹状体中的 DA 合成能力较低，而工作记忆容量高的受试者纹状体中的 DA 合成能力较高。
Evidence from psychopharmacological research has revealed that dopamine receptor agents have opposite effects on cognitive function depending on baseline levels of working memory capacity. These contrasting effects have been interpreted to reflect differential baseline levels of dopamine. Here we demonstrate for the first time that working memory capacity as measured by listening span predicts dopamine synthesis capacity in the striatum, indicating that subjects with low working memory capacity have low DA synthesis capacity in the striatum, whereas subjects with high working memory capacity have high DA synthesis capacity in the striatum.