Circulating soluble CD36 is a novel marker of liver injury in subjects with altered glucose tolerance
Circulating soluble CD36 is a novel marker of liver injury in subjects with altered glucose tolerance
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DOI：
10.1016/j.jnutbio.2008.05.009
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发表时间：
2009-06-01
影响因子：
5.6
通讯作者：
Ricart, Wifredo
中科院分区：
文献类型：
--
作者：
Fernandez-Real, Jose-Manuel;Handberg, Aase;Ricart, Wifredo
与胰岛素抵抗相关的肝损伤的特征是转氨酶活性轻度至中度升高。最近在人血浆中鉴定出可溶性形式的CD 36（sCD 36）。本研究的目的是评估血浆sCD 36，胰岛素敏感性（SI）和肝脏健康指标之间的关系。我们评估了一组来自普通人群的男性（n=117）。正如预期，血清（ALT），天冬氨酸转氨酶（AST）和γ-谷氨酰转移酶（GGT）与体重指数（BMI）和年龄呈正相关，与SI呈负相关（最小模型法）。在糖耐量改变的受试者中，循环sCD 36与ALT、AST和GGT呈正相关，但在糖耐量正常的受试者中不相关。关系的斜率差异显著（P= 0.01）。在糖耐量正常的受试者中，年龄、BMI和甘油三酯（而不是sCD 36）独立地导致29%的ALT变异。相比之下，SI和sCD 36独立地贡献了39%的ALT变异的受试者与改变葡萄糖耐量。ALT活性和sCD 36之间的相关性在一项独立的重复研究中得到证实。总之，循环sCD 36可能是葡萄糖耐量改变受试者肝损伤的新标志物。(C)2009 Elsevier Inc. All rights reserved.
Liver injury linked to insulin resistance is characterized by mild to moderate increases in aminotransferase activity. A soluble form of CD36 (sCD36) was recently identified in human plasma. The aim of this study was to evaluate the relationships among plasma sCD36, insulin sensitivity (SI) and indicators of liver health. We evaluated a cohort of men from the general population (n=117). As expected, serum (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) were associated positively with body mass index (BMI) and age and negatively with SI (minimal model method). Circulating sCD36 was positively associated with ALT, AST and GGT in subjects with altered glucose tolerance, but not in those with normal glucose tolerance. The difference in the slope of the relationships was significant (P=.01). Age, BMI and triglycerides (but not sCD36) contributed independently to 29% of ALT variance in subjects with normal glucose tolerance. In contrast, SI and sCD36 contributed independently to 39% of ALT variance in subjects with altered glucose tolerance. The correlation between ALT activity and sCD36 was confirmed in an independent, replication study. In summary, circulating sCD36 could represent a novel marker of liver injury in subjects with altered glucose tolerance. (C) 2009 Elsevier Inc. All rights reserved.