Effect of Selenium and Vitamin E Dietary Deficiencies on Chick Lymphoid Organ Development 1
Effect of Selenium and Vitamin E Dietary Deficiencies on Chick Lymphoid Organ Development 1
复制标题
DOI：
10.3181/00379727-182-42361
复制
发表时间：
1986-09
影响因子：
--
通讯作者：
J. Marsh;G. Combs;M. Whitacre;R. Dietert
中科院分区：
文献类型：
--
作者：
J. Marsh;G. Combs;M. Whitacre;R. Dietert
摘要从孵化时开始，用硒和/或维生素E缺乏或两者都充足的饲料喂养雏鸡。从7-35日龄的雏鸡中收集类囊器官（囊、胸腺和在某些情况下脾脏）。在实验期间监测饲喂这些饮食的雏鸡的生长以及淋巴器官的生长。通过组织学技术进一步评估初级淋巴器官的发育，并测定器官中维生素E（α-生育酚）和硒的含量。硒或维生素E的特定缺陷被发现显着损害法氏囊生长的组合缺乏。胸腺生长受损，只有由联合缺乏饮食。严重的组织病理学变化的囊导致的联合缺乏症，这些都是可检测的孵化后10-14天。这些变化的特征是上皮细胞逐渐变性，并伴随淋巴细胞耗竭。在胸腺中观察到类似的变化，尽管发展较慢且不太严重，但这是联合缺乏的结果。当监测血清和组织中维生素E和硒的水平时，观察到这些被特定的缺乏饮食快速且独立地耗尽。这些数据表明，初级淋巴器官的硒和维生素E的饮食缺乏症的主要目标，并提供了一个可能的机制，免疫功能可能会受损。
Abstract Diets specifically deficient in selenium (Se) and/or vitamin E or adequate in both nutrients were fed to chicks from the time of hatching. Lymphoid organs (bursa, thymus, and in some instances, spleen) were collected from chicks 7-35 days of age. Growth of the chicks fed these diets was monitored over the experimental period as was lymphoid organ growth. The development of the primary lymphoid organs was further assessed by histological techniques and the organ contents of vitamin E (α-tocopherol) and Se were determined. Specific deficiencies of either Se or vitamin E were found to significantly impair bursal growth as did a combined deficiency. Thymic growth was impaired only by the combined deficiency diet. Severe histopathological changes in the bursa resulted from the combined deficiency and these were detectable by 10-14 days after hatching. These changes were characterized by a gradual degeneration of the epithelium and an accompanying depletion of lymphocytes. Similar changes, although slower to develop and less severe, were observed in the thymus as a result of the combined deficiency. When both serum and tissue levels of vitamin E and Se were monitored, it was observed that these were rapidly and independently depleted by the specific deficiency diets. These data suggest that the primary lymphoid organs are major targets of Se and vitamin E dietary deficiencies and provide a possible mechanism by which immune function may be impaired.