Effects of ethanol and maternal nutritional status on fetal development.
Effects of ethanol and maternal nutritional status on fetal development.
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乙醇和母亲营养状况对胎儿发育的影响。
DOI：
10.1111/j.1530-0277.1985.tb05049.x
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Weinberg,J
中科院分区：
文献类型：
--
作者：
Weinberg,J
本研究探讨了酒精和孕妇营养状况对胎儿生长发育的相互影响。配制了三种液体饮食，蛋白质含量从次优到超优：饮食I提供18%千卡蛋白质和1.0千卡/毫升;饮食II和III分别提供25%和32%千卡蛋白质和1.2千卡/毫升。在所有情况下，酒精提供了总热量的36%。包括配对喂食和自由喂食对照组。我们发现，在整个妊娠期间，三种饮食方案的血液酒精水平一直很高。酒精摄入抑制体重增加，增加肾上腺重量和胎盘重量在怀孕的女性。酒精暴露胎仔的体重和脑重均降低。然而，发现酒精胎儿的相对脑重量增加，表明“大脑保留”。母亲的营养状况对发育结果没有重大影响。因此，酒精在总奶制品热量中所占的比例很高，增加膳食蛋白质水平并不能减轻酒精对胎儿发育的主要不良影响。
This study investigated the Interactive effects of alcohol and nutritional status of the pregnant female on fetal growth and development Three liquid diets were formulated ranging in protein content from suboptimal to supraoptimal: diet I provided 18% kcal as protein and 1.0 kcal/ml; diets II and III provided 25 and 32% kcal, respectively, as protein and 1.2 kcal/ml. In all cases, alcohol provided 36% of total calories. Both pair‐fed and ad libitum fed control groups were included. We found that blood alcohol levels were consistently high in all three diet regimens throughout gestation. Alcohol intake suppressed weight gains and increased adrenal weights and placenta weights in pregnant females. Both body weights and brain weights were reduced in alcohol‐exposed fetuses. However, relative brain weights were found to be increased in alcohol fetuses, indicating “brain sparing.” Maternal nutritional status had no major effect on developmental outcome. Thus, with alcohol administered as a high proportion of total dairy calories, increasing dietary protein levels did not attenuate the major adverse effects of alcohol on fetal development.