Out from under the wing: reconceptualizing the insect wing gene regulatory network as a versatile, general module for body-wall lobes in arthropods
Out from under the wing: reconceptualizing the insect wing gene regulatory network as a versatile, general module for body-wall lobes in arthropods
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DOI：
10.1098/rspb.2021.1808
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发表时间：
2021-12-22
影响因子：
4.7
通讯作者：
Jockusch，Elizabeth L.
中科院分区：
文献类型：
--
作者：
Fisher，Cera R.;Kratovil，Justin D.;Jockusch，Elizabeth L.
在节肢动物身体平面的进化中，特别是在节肢动物身体平面的进化中，身体平面的进化通常是通过序列上同源的身体部位的分化而发生的。最近，由基因表达的实验操作产生的同源异型转化，以及关于翅膀调控网络中基因表达和功能的比较数据，为昆虫进化中的一个古老问题提供了新的视角：昆虫翅膀是如何进化的？我们研究了一组与翅膀和体壁相关的10个基因在半变态昆虫OnCopeltus Fasciatus中的变质作用。我们的结果表明，与翅膀发育有关的基因在Ino。筋膜在成人体壁扁平的角质层外翻的发生中也起着类似的作用。我们发现翅膀的发育与体壁的其他双层外翻有着广泛的功能相似性。总体而言，我们的结果支持存在一个通用的发育模块，用于构建早于翅膀进化起源的双层角质上皮结构。我们探讨了将规范的翅膀模式网络重新概念化为双层体壁模式网络的后果，包括对翅膀同源性、翅膀的起源和新的双层身体壁结构的起源的长期争论的后果。最后，我们提出了三个可检验的预测，这三个预测是由这种重新概念化产生的。
Body plan evolution often occurs through the differentiation of serially homologous body parts, particularly in the evolution of arthropod body plans. Recently, homeotic transformations resulting from experimental manipulation of gene expression, along with comparative data on the expression and function of genes in the wing regulatory network, have provided a new perspective on an old question in insect evolution: how did the insect wing evolve? We investigated the metamorphic roles of a suite of 10 wing- and body-wall-related genes in a hemimetabolous insect,Oncopeltus fasciatus. Our results indicate that genes involved in wing development inO. fasciatusplay similar roles in the development of adult body-wall flattened cuticular evaginations. We found extensive functional similarity between the development of wings and other bilayered evaginations of the body wall. Overall, our results support the existence of a versatile development module for building bilayered cuticular epithelial structures that pre-dates the evolutionary origin of wings. We explore the consequences of reconceptualizing the canonical wing-patterning network as a bilayered body-wall patterning network, including consequences for long-standing debates about wing homology, the origin of wings and the origin of novel bilayered body-wall structures. We conclude by presenting three testable predictions that result from this reconceptualization.