"Missed" Mild Cognitive Impairment: High False-Negative Error Rate Based on Conventional Diagnostic Criteria
"Missed" Mild Cognitive Impairment: High False-Negative Error Rate Based on Conventional Diagnostic Criteria
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DOI：
10.3233/jad-150986
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发表时间：
2016-01-01
影响因子：
4
通讯作者：
Bondi, Mark W.
中科院分区：
文献类型：
--
作者：
Edmonds, Emily C.;Delano-Wood, Lisa;Bondi, Mark W.
轻度认知障碍 (MCI) 通常通过主观主诉、筛查措施、临床判断和单一记忆评分来诊断。我们之前的工作表明，这种方法很容易出现假阳性诊断错误。我们通过使用新的精算神经心理学标准对 520 名参与者进行诊断性重新分类，检查了该标准是否也会导致“假阴性”错误。结果显示假阴性错误率为 7.1%。参与者的神经心理学表现、脑脊液生物标志物和下降率提供了 MCI 诊断是必要的证据。 MCI“漏诊”病例的影响与前驱阿尔茨海默病的临床实践、研究和临床试验直接相关。
Mild cognitive impairment (MCI) is typically diagnosed using subjective complaints, screening measures, clinical judgment, and a single memory score. Our prior work has shown that this method is highly susceptible to false-positive diagnostic errors. We examined whether the criteria also lead to "false-negative" errors by diagnostically reclassifying 520 participants using novel actuarial neuropsychological criteria. Results revealed a false-negative error rate of 7.1%. Participants' neuropsychological performance, cerebrospinal fluid biomarkers, and rate of decline provided evidence that an MCI diagnosis is warranted. The impact of "missed" cases of MCI has direct relevance to clinical practice, research studies, and clinical trials of prodromal Alzheimer's disease.