Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner
Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner
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DOI：
10.1093/chemse/bjl016
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发表时间：
2006-10-01
期刊：
影响因子：
3.5
通讯作者：
Abe, Keiko
中科院分区：
文献类型：
--
作者：
Ohmoto, Makoto;Matsumoto, Ichiro;Abe, Keiko
两种电压依赖性钾通道KCNQ 1和KCNH 2在味蕾中表达，并被鉴定为参与表达磷脂酶C-β 2和TRPM 5（β 2/M5-TRCs）的味觉受体细胞复极化的强候选者。在细胞类型特异性表达中，KCNQ 1在大多数味蕾细胞中表达，包括β 2/M5-TRC，而KCNH 2在β 2/M5-TRC的一个子集中表达，与它们的味觉形态无关，例如甜味或苦味接收。KCNH 2的表达仅限于年轻的β 2/M5-TRCs。这些结果表明，除了β 2/M5-TRC之外的味蕾细胞被一些刺激去极化，并且β 2/M5-TRC具有细胞年龄依赖性的复极化分子机制。
Two voltage-dependent potassium channels, KCNQ1 and KCNH2, are expressed in the taste buds and were identified as strong candidates involved in the repolarization of taste receptor cells expressing phospholipase C-beta 2 and TRPM5 (beta 2/M5-TRCs). In cell type-specific expression, KCNQ1 was expressed in most taste bud cells, including beta 2/M5-TRCs, whereas KCNH2 was expressed in a subset of beta 2/M5-TRCs with no correlation with their taste modality, such as sweet or bitter taste reception. Expression of KCNH2 was restricted to young beta 2/M5-TRCs. These results suggest that taste bud cells other than beta 2/M5-TRCs are depolarized by some stimuli and also that beta 2/M5-TRCs have cell age-dependent molecular mechanisms of repolarization.