High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns
High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns
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DOI：
10.3109/10715760903548245
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发表时间：
2010-04-01
影响因子：
3.3
通讯作者：
Togari, Hajime
中科院分区：
文献类型：
--
作者：
Hussein, Mohamed Hamed;Daoud, Ghada A.;Togari, Hajime
目的是解释缺氧缺血性脑损伤（HIE）的发展中的差异，在一些窒息的新生儿，而不是其他人。40名新生儿根据其出生后第5天的脑脊液神经元特异性烯醇化酶（CSF-NSE）水平进行分类;第1组为低NSE组（n = 25）。其余15例NSE阳性新生儿分为无HIE组（n = 10，第2组）和HIE组（n = 5，第3组）。检测脑脊液神经元特异性烯醇化酶（CSF-NSE）、总过氧化氢（TH）、生物抗氧化能力（BAPs）、12种细胞因子及促红细胞生成素（EPO）。TH/BAP测定氧化应激指数（OSI）。测定了三种EPO系列稀释液的BAP。CSF-NSE和TH和平均OSI在组3中较高。第2组的IL-8和平均BAP高于第1组。EPO在第3组中检测较少。EPO系列稀释液与其BAP相关。代偿性抗氧化剂和IL-8升高对围产期窒息性脑损伤具有保护作用。EPO的抗氧化作用可能具有神经保护作用。
The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant-potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.