Association of sleep-wake rhythm and sleep quality with endothelial function in young adults.
Association of sleep-wake rhythm and sleep quality with endothelial function in young adults.
复制标题
青壮年睡眠-觉醒节律和睡眠质量与内皮功能的关系。
DOI：
10.5935/1984-0063.20220050
复制
发表时间：
2022-07
期刊：
影响因子：
1.6
通讯作者：
Murohara, Toyoaki
中科院分区：
文献类型：
--
作者：
Nakashima, Honoka;Noda, Akiko;Tamura, Anna;Nagai, Michiaki;Okuda, Masato;Okumura, Takahiro;Yasuma, Fumihiko;Murohara, Toyoaki
现代社会的环境可能会扰乱睡眠-觉醒的节奏。我们的目的是研究睡眠-觉醒节律与内皮功能和睡眠质量的关系。健康大学生31名，平均年龄(20.4±1.8)岁。应用高分辨率超声评价血管内皮依赖性血流介导的肱动脉扩张百分率[%FMD：(最大径-基线直径)/基线直径x 100]。我们还使用活动记录仪测量了总睡眠时间(TST)、睡眠效率和睡眠时间(睡前和醒来时间的中点)的标准差(SD)。睡眠-觉醒节律不规律被定义为就寝时间或起床时间移动两小时或更长时间。不规则组的%FMD值和睡眠效率显著低于正常组(%FMD6.1±2.4vs.10.9±2.3p&t；0.001，睡眠效率：92.2vs.95.9±2.8%，p=0.027)，而≥组和tst+lt6h组和tst-TST6h组的%FMD值差异无统计学意义。%FMD与睡眠计时标准差显著相关(r=-0.481，p=0.006)。包括年龄、性别、TST、睡眠效率和睡眠时间标准差在内的多元回归分析显示，睡眠时间标准差是影响FMD的显著因素(？=-0.454，p=0.017)。我们的发现表明，不规则的睡眠-觉醒节律和糟糕的睡眠质量可能会对年轻人的内皮功能产生不利影响。
The environment in modern society could disturb the sleep-wake rhythm. We aimed to study the association of sleep-wake rhythm with endothelial function and sleep quality. Thirty-one healthy university students (mean age: 20.4±1.8 years) were enrolled. The endothelial function was evaluated with the percent endothelium-dependent flow-mediated dilation of the brachial artery [%FMD: (maximum diameter - baseline diameter)/baseline diameter x 100] using the high-resolution ultrasonography. We also measured the total sleep time (TST), sleep effciency, and the standard deviation (SD) of sleep timing (midpoint between bedtime and wake-up time) using the actigraphy. The irregular sleep-wake rhythm was defined as having the shift of bedtime or wake-up time for two hours or longer. The %FMD and sleep efficiency were significantly lower in the irregular group than regular group (%FMD: 6.1±2.4 vs. 10.9±2.3, p<0.001, sleep effciency: 92.2±5.8 vs. 95.9±2.8%, p=0.027), whereas there was no significant difference in %FMD between the two groups of TST <6 hours and TST ≥6 hours. The %FMD was significantly correlated with SD of sleep timing (r=-0.481, p=0.006). Multiple regression analyses, including age, sex, TST, sleep effciency, and SD of sleep timing revealed that the SD of sleep timing was a significant factor associated with %FMD (ß=-0.454, p=0.017). Our findings suggest that the irregular sleep-wake rhythm and poor sleep quality could have adverse effects on endothelial function in young adults.