Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
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通过网络药理学预测 VEGF-C 作为柑橘纯总黄酮对抗小鼠 NAFLD 的关键靶点
DOI：
10.3389/fphar.2019.00582
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发表时间：
2019-06-04
影响因子：
5.6
通讯作者：
Chen, Zhiyun
中科院分区：
文献类型：
--
作者：
Hong, Wei;Li, Songsong;Chen, Zhiyun
柑橘纯总黄酮(PTFC)能有效减轻非酒精性脂肪性肝病(NAFLD)的症状。我们之前的微阵列分析揭示了PTFC治疗NAFLD过程中重要信号通路的变化。然而，在NALFD的发展过程中发挥重要作用的潜在的核心基因可能是PTFC的靶点，目前还没有确定。在本研究中，我们通过网络药理学分析，预测血管内皮生长因子-C(VEGF-C)是PTFC治疗NAFLD的潜在关键分子靶点。本文提出的网络药理学方法为理解PTFC在NAFLD发展过程中的作用机制提供了重要线索。
Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous microarray analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targeted by PTFC, which play important roles in the progression of NALFD are yet to be identified. In this study, we predicted the vascular endothelial growth factor-C (VEGF-C) as potential key molecular target of PTFC against NAFLD via network pharmacology analysis. The network pharmacology approach presented here provided important clues for understanding the mechanisms of PTFC treatment in the development of NAFLD.