Regional inhibitory effect of ethanol on monoamine synthesis regulation within the brain.
Regional inhibitory effect of ethanol on monoamine synthesis regulation within the brain.
复制标题
乙醇对大脑内单胺合成调节的区域抑制作用。
DOI：
10.1016/0006-2952(80)90352-4
复制
发表时间：
1980
影响因子：
5.8
通讯作者：
Roth,RH
中科院分区：
文献类型：
--
作者：
Umezu,K;Bustos,G;Roth,RH
Catecholamine biosynthesis from labeled tyrosine was examined in hippocampal and olfactory tubercle slices. The presence of depolarizing concentrations of potassium (25–55 mM) resulted in significant increases in catecholamine synthesis in both tissue preparations. Following depolarization of slices in 25 mM potassium, the major portion of newly synthesized catecholamine was retained in the tissue whereas incubation in 55 mM potassium resulted in a significant portion of the newly synthetized catechols being released into the media. Addition of ethanol in concentrations of 0.2–0.8% (w/v) to tissue slices prepared from brain regions rich in dopaminergic nerve terminals, such as olfactory tubercles, caused a dramatic reduction in dopamine synthesis from labeled tyrosine induced by potassium depolarization. The ability of ethanol to inhibit the potassium-induced acceleration of catecholamine biosynthesis appeared to be related to the dopaminergic innervation of the tissue. Catecholamine synthesis in slices of depolarized hippocampi, tissue which is relatively free from substantial dopaminergic innervation, was unaffected by ethanol in concentrations as high as 1.2% (w/v). These results are discussed in terms of the selectivity and mechanisms of the ethanol-induced effects.
