Current and emerging therapies for corneal neovascularization.

Current and emerging therapies for corneal neovascularization.
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DOI:
10.1016/j.jtos.2018.06.004
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发表时间:
2018-10
期刊:
The ocular surface
影响因子:
--
通讯作者:
Holland EJ
Holland EJ
中科院分区:
其他
文献类型:
--
作者:
Roshandel D;Eslani M;Baradaran-Rafii A;Cheung AY;Kurji K;Jabbehdari S;Maiz A;Jalali S;Djalilian AR;Holland EJ

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角膜是独一无二的,因为它完全无血供。角膜新生血管形成(CNV)可由多种病因引起,包括接触透镜佩戴;角膜感染;以及由于炎症、化学损伤和角膜缘干细胞缺乏引起的眼表疾病。管理主要集中在病因学和病理生理学引起的CNV,并涉及医疗和手术的选择。由于炎症是CNV病理生理学的关键因素,因此皮质类固醇和其他抗炎药物仍然是治疗的主要手段。抗VEGF疗法越来越受欢迎,以预防许多病因中的CNV。根据病因和对药物治疗的反应,包括血管闭塞和眼表重建在内的手术选择是其他选择。未来的治疗应该为CNV的管理提供更有效的治疗选择。
The cornea is unique because of its complete avascularity. Corneal neovascularization (CNV) can result from a variety of etiologies including contact lens wear; corneal infections; and ocular surface diseases due to inflammation, chemical injury, and limbal stem cell deficiency. Management is focused primarily on the etiology and pathophysiology causing the CNV and involves medical and surgical options. Because inflammation is a key factor in the pathophysiology of CNV, corticosteroids and other anti-inflammatory medications remain the mainstay of treatment. Anti-VEGF therapies are gaining popularity to prevent CNV in a number of etiologies. Surgical options including vessel occlusion and ocular surface reconstruction are other options depending on etiology and response to medical therapy. Future therapies should provide more effective treatment options for the management of CNV.
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