Synaptic plasticity in the amygdala in a visceral pain model in rats
Synaptic plasticity in the amygdala in a visceral pain model in rats
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DOI：
10.1016/j.neulet.2003.12.027
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发表时间：
2004-05-06
影响因子：
2.5
通讯作者：
Neugebauer, V
中科院分区：
文献类型：
--
作者：
Han, JS;Neugebauer, V
杏仁核在疼痛的情绪-情感成分中起着关键作用。本研究首次分析了内脏疼痛模型中杏仁核中央核（CeA）的突触可塑性。用膜片钳全细胞记录了对照大鼠和酶酶酶诱导结肠炎大鼠（诱导后6 h）脑切片CeA后囊部分的神经元。电刺激脑桥臂旁区（PB）和杏仁核基底外侧（BLA）传入神经可引起单突触反应。结肠炎大鼠在痛觉性PB-CeA突触中观察到突触传递增强，而在多模态BLA-CeA突触中没有。结肠炎大鼠CeA神经元的动作电位频率增加，表明其兴奋性增强。我们的结果为CeA在内脏疼痛中的重要作用提供了新的证据。2003爱思唯尔爱尔兰有限公司版权所有。
The amygdala plays a key role in the emotional-affective component of pain. This study is the first to analyze synaptic plasticity in the central nucleus of the amygdala (CeA) in a model of visceral pain. Whole-cell patch-clamp recordings were made from neurons in the laterocapsular part of the CeA in brain slices from control rats and rats with zymosan-induced colitis (>6 h postinduction). Monosynaptic responses were evoked by electrical stimulation of afferents from the pontine parabrachial area (PB) and from the basolateral amygdala (BLA). Enhanced synaptic transmission was observed at the nociceptive PB-CeA synapse, but not at the polymodal BLA-CeA synapse, in rats with colitis. The frequency of action potentials evoked by direct current injection was increased in CeA neurons from colitis rats, suggesting enhanced neuronal excitability. Our results provide novel evidence for an important role of the CeA in visceral pain. (C) 2003 Elsevier Ireland Ltd. All rights reserved.