Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis The UK TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry
Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis The UK TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry
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DOI：
10.1016/j.jacc.2011.08.050
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发表时间：
2011-11-08
影响因子：
24
通讯作者：
Mullen, Michael J.
中科院分区：
文献类型：
--
作者：
Moat, Neil E.;Ludman, Peter;Mullen, Michael J.
目的是确定现实世界中接受经导管主动脉瓣植入术（TAVI）治疗的患者群体的特征，无论其技术或通路如何，并评估其中长期临床结果。背景：虽然有大量的数据与TAVI后的早期临床结果有关，但在任何显著数量的患者中，关于1年以上结果的数据很少。方法建立英国TAVI（英国经导管主动脉瓣植入术）登记处，报告在英国进行的所有TAVI手术的结果。截至2009年12月31日，前瞻性地收集了870例接受877次TAVI手术的患者的数据。截至2010年12月，已报告死亡率状况的患者中100%实现了死亡率跟踪。结果30天生存率为92.9%，1年生存率为78.6%，2年生存率为73.7%。在30天至1年期间，存活率明显下降。在单变量模型中，肾功能不全、冠状动脉疾病和非经股入路对生存率有显著不利影响；而左心室功能（射血分数）
Objectives The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term.Background Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients.Methods The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010.Results Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction