The effect of prenatal nicotine on expression of nicotine receptor subunits in the fetal brain
The effect of prenatal nicotine on expression of nicotine receptor subunits in the fetal brain
复制标题
产前尼古丁对胎儿大脑尼古丁受体亚基表达的影响
DOI：
10.1016/j.neuro.2008.04.015
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发表时间：
2008-07-01
期刊：
影响因子：
3.4
通讯作者：
Xu, Zhice
中科院分区：
文献类型：
--
作者：
Lv, Juanxiu;Mao, Caiping;Xu, Zhice
以前的研究表明，产前接触尼古丁与胎儿发育异常有关，包括胎儿脑损伤。本研究确定了不同妊娠期母体给予尼古丁对胎鼠脑尼古丁受体亚基的影响。在妊娠早期和中期对母体大鼠皮下注射尼古丁可降低胎仔血PO2，增加胎仔血PCO2和血红蛋白，并降低胎仔脑重量。在胎儿大脑中的烟碱乙酰胆碱受体（nAChRs）的mRNA丰度显着改变，产前治疗与尼古丁在怀孕期间。大鼠胎仔在产前暴露于尼古丁后，其大脑中的胎仔α（2）、α（4）、α（7）和β（2）单位显著增加。而胎脑α（3）、α（5）、β（3）和β（4）单位的mRNA表达无变化。结果表明，产前尼古丁可在基因水平上改变胎儿脑内nAChR β和P亚基的发育，并与胎儿脑发育受限和宫内缺氧有关。(C)2008年爱思唯尔公司All rights reserved.
Previous studies have suggested that prenatal exposure to nicotine is associated with abnormal development in fetuses, including fetal brain damage. The present study determined the effect of maternal administration of nicotine during different gestational periods on brain nicotine receptor subunits in fetal rats. Subcutaneous injections of nicotine in maternal rats from the early and middle gestation decreased fetal blood PO2, increased fetal blood PCO2 and hemoglobin, and decreased fetal brain weight. The nicotinic acetylcholine receptor (nAChRs) mRNA abundance in the fetal brain was significantly changed by prenatal treatment with nicotine during pregnancy. Fetal alpha(2), alpha(4), alpha(7), and beta(2) units were significantly increased in the brain by prenatal exposure to nicotine in rat fetuses. However, the expression of mRNA of fetal brain alpha(3), alpha(5), beta(3), and beta(4) units were not changed. The results showed that prenatal nicotine can change the development of both (x and P subunits of nAChRs in the fetal brain at gene level in association with restriction of fetal brain growth and in utero hypoxia. (C) 2008 Elsevier Inc. All rights reserved.