Vasoactive compound effects on autoregulating versus nonautoregulating intestinal and renal circulations in young swine.
Vasoactive compound effects on autoregulating versus nonautoregulating intestinal and renal circulations in young swine.
复制标题
血管活性化合物对幼猪的自动调节与非自动调节肠和肾循环的影响。
DOI：
10.1159/000242823
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Owusu,K
中科院分区：
文献类型：
--
作者：
Buckley,NM;Diamant,S;Frasier,ID;Owusu,K
在用戊巴比妥麻醉的禁食猪中，在原位灌注的12个肾脏和10个空肠制备物中检查单次动脉内注射去甲肾上腺素、组胺和腺苷的血管阻力变化。阈值剂量较高，其他反应幅度较小，在非自动调节肾循环的1周龄和空肠循环的2周龄比自动调节循环的1个月大。这些结果表明，成熟的自动调节能力和血管扩张组胺和腺苷受体之间的相关性。
Vascular resistance changes to single intra-arterial injections of norepinephrine, histamine and adenosine were examined in 12 kidney and 10 jejunum preparations perfused in situ in fasting swine anesthetized with pentobarbital. Threshold doses were higher and other response magnitudes were smaller in the nonautoregulating renal circulation of 1-week-olds and jejunal circulation of 2-week-olds than in âutoregulating circulations of 1-month-olds. These results suggest a correlation between maturation of autoregulatory capability and of vasodilator histamine and adenosine receptors.