A possible attenuation of stress-induced increases in striatal dopamine metabolism by the expression of non-functional masticatory activity in the rat
A possible attenuation of stress-induced increases in striatal dopamine metabolism by the expression of non-functional masticatory activity in the rat
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DOI：
10.1046/j.0909-8836.1999.eos107607.x
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发表时间：
1999-12-01
影响因子：
1.9
通讯作者：
García-Vallejo, P
中科院分区：
文献类型：
--
作者：
Gómez, FM;Giralt, MT;García-Vallejo, P
人们认为，口腔功能异常的表达可能提供了一个出口的压力或侵略man. Stress-induced增加中枢去甲肾上腺素能神经传递被衰减在大鼠允许咬在压力期间。纹状体多巴胺能神经传递参与啮齿动物口腔运动异常的发生。由于夹尾是最明显地引起非功能性咀嚼活动（NFMA）的应激源，并且也增加大鼠纹状体多巴胺（DA）活性，因此我们研究夹尾期间NFMA的表达是否可以改变由该应激源引起的纹状体多巴胺能神经传递的变化。对大鼠进行夹尾5分钟，并记录NFMA显示的持续时间。作为多巴胺能活性的指标，3，4-二羟基苯丙氨酸（DOPA）的积累和DA和3，4-二羟基苯乙酸（DOPAC）的含量在两个纹状体测定高效液相色谱法。纹状体多巴积累类似地增加，与对照组相比，无论是在夹尾期间显示NFMA的大鼠还是在夹尾期间不显示NFMA的大鼠。然而，纹状体DOPAC含量的增加，报告24分钟后的压力会议，显示NFMA的动物较低。这些结果提供了进一步的证据支持的假设，即表达的功能异常咀嚼活动减弱的影响，压力对中央儿茶酚胺能神经传递。
It is thought that the expression of oral parafunctions may provide an outlet for stress or aggressiveness in man. Stress-induced increases in central noradrenergic neurotransmission are attenuated in rats which are allowed to bite during stress. Striatal dopaminergic neurotransmission is involved in the genesis of parafunctional oral movements in rodents. As tail pinch is the stressor which most clearly provokes non-functional masticatory activity (NFMA), and also increases striatal dopamine (DA) activity in rats, we investigated whether the expression of NFMA during tail pinch could modify the changes in striatal dopaminergic neurotransmission induced by this stressor. Rats were subjected to tail pinch for 5 min, and the duration of the NFMA displayed was recorded. As an index of dopaminergic activity, 3,4-dihydroxyphenylalanine (DOPA) accumulation and DA and 3,4-dihydroxyphenylacetic (DOPAC) contents in both striata were determined by high-performance liquid chromatography. Striatal DOPA accumulation was similarly increased in relation to control, both in rats which did and did not display NFMA during tail pinch. However, the increases in striatal DOPAC contents, reported 24 min after the stress session, were lower in animals which had displayed NFMA. These results provide further evidence in support of the assumption that the expression of parafunctional masticatory activity attenuates the effects of stress on central catecholaminergic neurotransmission.