RADIATION DOSE-VOLUME EFFECTS IN THE HEART
RADIATION DOSE-VOLUME EFFECTS IN THE HEART
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DOI：
10.1016/j.ijrobp.2009.04.093
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发表时间：
2010-01-01
影响因子：
7
通讯作者：
Marks, Lawrence B.
中科院分区：
文献类型：
--
作者：
Gagliardi, Giovanna;Constine, Louis S.;Marks, Lawrence B.
文献回顾，以确定急性和晚期辐射诱发心脏病的主要临床和剂量体积预测。大多数心脏毒性的明确定量剂量和/或体积依赖性尚未显示，主要是因为数据稀缺。一些临床因素，如年龄，合并症和阿霉素的使用，似乎增加了损伤的风险。现有的剂量-体积数据，以及为今后的调查，以更好地定义辐射引起的心脏损伤的建议。(C)2010年爱思唯尔公司
The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity h as not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury. (C) 2010 Elsevier Inc.