Near Full-Length Genome Sequences of Two Novel HIV-1 Recombinant Forms Detected in Henan Province, China.
Near Full-Length Genome Sequences of Two Novel HIV-1 Recombinant Forms Detected in Henan Province, China.
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DOI：
10.1089/aid.2016.0027
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发表时间：
2016-04
影响因子：
1.5
通讯作者：
Tian-yi Li;G. Sun;Dijing Jia;Changrong Sun;Zhe Wang;Si-yang Liu;Yongjian Liu;Han-ping Li;Xiao-lin Wang;Jingyun Li;Lin Li
中科院分区：
文献类型：
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作者：
Tian-yi Li;G. Sun;Dijing Jia;Changrong Sun;Zhe Wang;Si-yang Liu;Yongjian Liu;Han-ping Li;Xiao-lin Wang;Jingyun Li;Lin Li
近年来，河南省通过性接触感染的人群是艾滋病传播增长最快的人群。在这里，我们报告了两种新的人类免疫缺陷病毒1型（HIV-1）重组形式检测到一个全面的HIV-1分子流行病学研究中异性恋者。两种新型HIV-1重组分离株的近全长基因组的重组分析：01B.CN.2012.11092是CRF01_AE，其部分被414 bp的亚型B'片段取代（根据HXB 2校准品，从4482-4896）。01BC.CN.2011.11312由三段（CRF01_AE/CRF_07BC/B '）组成，根据HXB 2校准品，断点为4274和4833。它们与国内报道的重组菌株不同。
In recent years, the population infected through sexual contact has seen the fastest growing prevalence of HIV transmission in Henan province, China. Here, we report two novel human immunodeficiency virus type 1 (HIV-1) recombinant form detected from a comprehensive HIV-1 molecular epidemiologic study among heterosexuals. Recombinant analyses of the near full-length genome of the two novel HIV-1 recombinant isolates: 01B.CN.2012.11092 was CRF01_AE that was partly replaced by a subtype B' fragment of 414 bp (from 4482-4896 according to the HXB2 calibrator). 01BC.CN.2011.11312 was composed of three segments (CRF01_AE/CRF_07BC/B') with breakpoints 4274 and 4833 according to the HXB2 calibrator. They are different from previously identified recombinant strains reported in China.