Chronic pelvic pain syndrome/chronic prostatitis affect the acrosome reaction in human spermatozoa
Chronic pelvic pain syndrome/chronic prostatitis affect the acrosome reaction in human spermatozoa
复制标题
DOI：
10.1007/s00345-005-0038-y
复制
发表时间：
2006-02-01
影响因子：
3.4
通讯作者：
Weidner, W
中科院分区：
文献类型：
--
作者：
Henkel, R;Ludwig, M;Weidner, W
男性生殖道炎症是男性生育力低下的一个重要因素，其中不同的介质会损害精子膜。由于顶体反应（AR）最终是一种膜功能，本研究旨在调查慢性盆腔疼痛综合征对顶体反应的影响。在总共 56 名慢性盆腔疼痛综合征 NIH IIIA 和 NIH IIIB 患者中，测定了前列腺按摩后射精和尿液中的白细胞浓度、精子浓度、活力、活力和形态。对照组（n = 95）由精子正常且已证明没有炎症迹象的患者组成。与对照组相比，两组患者的精子形态（P < 0.0001）和精子浓度（P < 0.002）均较差。此外，虽然最大 AR 不受影响，但 AR 的诱导能力显着降低（P < 0.004），自发 AR 增加（P < 0.02）。我们的数据清楚地表明炎症对顶体功能有显着影响，这可能是由 ROS 等炎症介质介导的。
Male genital tract inflammations constitute an important factor of male subfertility in which different mediators are discussed damaging sperm membranes. As acrosome reaction (AR) is ultimately a membrane function, this study aimed at investigating the effects of the chronic pelvic pain syndrome on AR. In a total of 56 patients with chronic pelvic pain syndrome NIH IIIA and NIH IIIB, AR, concentration of leucocytes in ejaculate and urine after prostate massage, sperm concentration, motility, vitality and morphology were determined. The control group (n=95) consisted of patients with normozoospermia and proven absence of signs of inflammation. Compared to the control, both patients groups showed poorer sperm morphology (P < 0.0001) and sperm concentration (P < 0.002). In addition, while maximum AR was not affected, inducibility of AR was significantly lower (P < 0.004) and spontaneous AR increased (P < 0.02). Our data clearly demonstrate a significant influence of the inflammation on acrosomal functionality, which could be mediated by inflammatory mediators like ROS.