Social Context and Reward Sensitivity Enhance Corticostriatal Function during Experiences of Shared Rewards.
Social Context and Reward Sensitivity Enhance Corticostriatal Function during Experiences of Shared Rewards.
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社会背景和奖励敏感性在共享奖励的经历中增强皮质纹状体功能。
DOI：
10.1101/2023.10.19.562908
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Fareri,DominicS
中科院分区：
文献类型：
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作者：
Zaff,Ori;Wyngaarden,JamesB;Dennison,JeffreyB;Sazhin,Daniel;Chein,Jason;McCloskey,Michael;Alloy,LaurenB;Jarcho,JohannaM;Smith,DavidV;Fareri,DominicS
尽管之前的研究已经证明，当与密切的社会联系分享奖励时，纹状体的反应会增强，但人们对个体差异如何影响腹侧纹状体（VS）在社会背景下体验奖励时的激活和连接知之甚少。鉴于自我报告的奖励敏感性和物质使用水平与VS激活的差异有关，我们着手研究这些因素是否与社交环境中神经奖励反应的增强独立相关。在这项预先注册的研究中，参与者（N=45）在玩纸牌猜谜游戏时接受了fMRI，在这个游戏中，正确或不正确的猜测会导致与亲密朋友，陌生人（同盟者）或非人类伙伴平均分享的金钱收益和损失。与我们之前的工作一致，我们发现当与社交密切的同伴分享奖励时，VS激活增加，而不是与网络外的陌生人分享奖励。随着自我报告的奖励敏感性的增加，与朋友和陌生人分享奖励的VS反应差异减小。我们还发现，当与亲密的朋友而不是陌生人分享奖励时，VS和颞顶交界处之间的连通性增强。最后，探索性分析显示，随着奖励敏感性和亚临床物质使用的增加，与右梭状脸区域的VS连接的差异随着社会背景的变化而增加。这些发现表明，对亲密朋友的反应可能与个人奖励敏感性或亚临床物质使用习惯有关;这些因素可能共同预测未来精神健康障碍的风险。
Although prior research has demonstrated enhanced striatal response when sharing rewards with close social connections, less is known about how individual differences affect ventral striatal (VS) activation and connectivity when experiencing rewards within social contexts. Given that self-reported reward sensitivity and level of substance use have been associated with differences in VS activation, we set out to investigate whether these factors would be independently associated with enhancements to neural reward responses within social contexts. In this pre-registered study, participants (N=45) underwent fMRI while playing a card guessing game in which correct or incorrect guesses resulted in monetary gains and losses that were shared evenly with either a close friend, stranger (confederate), or non-human partner. Consistent with our prior work, we found increased VS activation when sharing rewards with a socially close peer as opposed to an out-of-network stranger. As self-reported reward sensitivity increased, the difference in VS response to rewards shared with friends and strangers decreased. We also found enhanced connectivity between the VS and temporoparietal junction when sharing rewards with close friends as opposed to strangers. Finally, exploratory analyses revealed that as reward sensitivity and sub-clinical substance use increase, the difference in VS connectivity with the right fusiform face area increases as a function of social context. These findings demonstrate that responsivity to the context of close friends may be tied to individual reward sensitivity or sub-clinical substance use habits; together these factors may inform predictions of risk for future mental health disorders.