Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo.
Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo.
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发表时间：
1999-06
期刊：
影响因子：
11.2
通讯作者：
K. Schorr;Minglin Li;U. Bar-Peled;Albert Lewis;Alonso Heredia;Bernadette C. Lewis;C. Knudson;S. Korsmeyer;Richard Jäger;Hans Weiher;Priscilla A. Furth
中科院分区：
文献类型：
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作者：
K. Schorr;Minglin Li;U. Bar-Peled;Albert Lewis;Alonso Heredia;Bernadette C. Lewis;C. Knudson;S. Korsmeyer;Richard Jäger;Hans Weiher;Priscilla A. Furth
在乳腺退化的两个阶段中，将 Bcl-2 功能的获得与 Bax 功能的丧失对乳腺上皮细胞存活的影响进行比较。 Bcl-2 功能获得在第一阶段减少了 50% 的细胞凋亡，在第二阶段增加了 70% 的细胞存活率。 Bax 的完全缺失使第一阶段的细胞凋亡减少了 20%，而没有第二阶段的影响。 Bax 的部分缺失是无效的，但与 Bcl-2 增益相结合时，细胞存活率增加了 2.4 倍。 Bcl-2 功能的获得比 Bax 功能的丧失在调节体内乳腺上皮细胞存活方面更有效。
The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.