A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
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DOI：
10.1016/j.bmcl.2011.12.095
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发表时间：
2012-03
影响因子：
2.7
通讯作者：
Guanghui Wang-;Xiaoyu Guo;Haifeng Chen;Ting Lin;Yang Xu;Quancheng Chen;Jie Liu;Jin-Zhang Zeng
中科院分区：
文献类型：
--
作者：
Guanghui Wang-;Xiaoyu Guo;Haifeng Chen;Ting Lin;Yang Xu;Quancheng Chen;Jie Liu;Jin-Zhang Zeng
在从云南石竹中分离鉴定的七种天然白藜芦醇类似物中，我们发现白藜芦醇B（PYB，反式-3,4'-二羟基-2',3',5-三甲氧基芪）比白藜芦醇更能有效地抑制HepG2肝癌细胞的生长。 PYB 对 HepG2 细胞的抑制作用是由于其诱导 G2/M 细胞周期停滞和凋亡。 PYB 诱导 G2/M 期细胞周期阻滞与其上调 Cyclin B1 相关，而诱导细胞凋亡则与其下调 Bcl-2 和上调 Bax 相关。我们的体外侵袭/迁移试验还表明，PYB 可以抑制肝细胞癌细胞的侵袭。
Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis ROLFE, we found phoyunbene B (PYB, trans-3,4′-dihydroxy-2′,3′,5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells.