Mitral ratio of peak early to late diastolic filling velocity as a predictor of mortality in middle-aged and elderly adults - The strong heart study
Mitral ratio of peak early to late diastolic filling velocity as a predictor of mortality in middle-aged and elderly adults - The strong heart study
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DOI：
10.1161/01.cir.0000015076.37047.d9
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发表时间：
2002-04-23
期刊：
影响因子：
37.8
通讯作者：
Devereux, RB
中科院分区：
文献类型：
--
作者：
Bella, JN;Palmieri, V;Devereux, RB
背景-随着年龄的增长，左室充盈在舒张早期趋于减少，降低二尖瓣舒张早期峰值充盈速度与舒张晚期峰值充盈速度的比值（E/A）。然而，低或高的E/A在老年人的预后意义仍然C要阐明在人口为基础的samples.Methods和结果多普勒超声心动图进行了分析，在3008年美国印第安人参加第二次强心研究检查谁没有超过轻度二尖瓣或主动脉瓣返流。在多普勒超声心动图检查后，对参与者平均随访3年，以评估与E/A 1.5相关的全因和心源性死亡风险：2429名（81%）参与者E/A比值正常，490名（16%）参与者E/A 1.5。E/A 1.5组的全因死亡率更高（12%和13%对6%），心源性死亡率也更高（4.5%和6.5%对1.6%，均P
Background-With aging, left ventricular filling tends to decrease in early diastole, reducing the mitral ratio of peak early to late diastolic filling velocity (E/A). However, the prognostic significance of low or high E/A in older adults remains C to be elucidated in population-based samples.Methods and Results-Doppler echocardiograms were analyzed in 3008 American Indian participants in the second Strong Heart Study examination who had no more than mild mitral or aortic regurgitation. Participants were followed for a mean of 3 years after Doppler echocardiography to assess risks of all-cause and cardiac death associated with E/A 1.5: 2429 (81%) participants had normal E/A ratio, 490 (16%) had E/A 1.5. All-cause mortality was higher with E/A 1.5 (12% and 13% versus 6%), as was cardiac mortality (4.5% and 6.5% versus 1.6% both P