Acute depressor effect of alcohol in patients with essential hypertension.
Acute depressor effect of alcohol in patients with essential hypertension.
复制标题
酒精对原发性高血压患者的急性降压作用。
作者：
Yuhei Kawano;H. Abe;Shunichi Kojima;Terunao Ashida;Kaoru Yoshida;Masahito Imanishi;Hiroki Yoshimi;Genjiro Kimura;M. Kuramochi;Teruo Omae
为了研究酒精对血压影响的时间过程，我们研究了高血压患者对单次中等剂量酒精的动态血压、神经体液变量和血流动力学的反应。在标准化条件下对16名日本男性（22-70岁）进行了检查，这些男性患有原发性高血压，并且是习惯性饮酒者。在酒精摄入日，他们在晚餐时摄入1 ml/kg乙醇（伏特加），在对照日，他们饮用非酒精饮料。两个阶段的顺序是随机的。酒精摄入期的平均动态血压低于对照期（125 +/- 3/74 +/- 2 vs 132 +/- 4/78 +/- 2 mm Hg，p <0.05），酒精的显著降压作用持续至饮酒后8小时。第二天的血压在饮酒或不饮酒的情况下没有差异。酒精的急性水肿作用与心率和心输出量的增加以及超声心动图测定的全身血管阻力的降低有关。血浆儿茶酚胺水平和肾素活性在晚餐后2小时显著升高，而加压素和钾水平在饮酒当天下降。两个时期的血糖和血清胰岛素水平相当。三名患者显着的酒精引起的潮红有更大的肿胀和心动过速反应比那些谁没有表现出酒精引起的潮红。酒精引起的平均血压变化与年龄、基线血压和血浆去甲肾上腺素变化呈负相关。这些结果表明，急性酒精摄入的主要影响是通过全身血管舒张降低血压的高血压受试者。动态血压监测可能有助于评估习惯性饮酒者的血压。
To investigate the time course of the effects of alcohol on blood pressure, we studied the response of ambulatory blood pressure, neurohumoral variables, and hemodynamics to a single moderate dose of alcohol in hypertensive patients. Sixteen Japanese men (22-70 years old) with essential hypertension who were habitual drinkers were examined under standardized conditions. On the alcohol intake day, they ingested 1 ml/kg ethanol (vodka) at dinner, and on the control day they consumed a nonalcoholic beverage. The order of the two periods was randomized. Mean ambulatory blood pressure was lower in the alcohol intake period than in the control period (125 +/- 3/74 +/- 2 versus 132 +/- 4/78 +/- 2 mm Hg, p less than 0.05), and the significant depressor effect of alcohol lasted for up to 8 hours after drinking. Blood pressure on the next day did not differ with or without alcohol intake. The acute hypotensive effect of alcohol was associated with an increase in heart rate and cardiac output and with a decrease in systemic vascular resistance as determined by echocardiography. Plasma catecholamine levels and renin activity rose significantly at 2 hours after dinner, whereas vasopressin and potassium levels fell on the alcohol day. Blood glucose and serum insulin levels were comparable between the two periods. Three patients with marked alcohol-induced flush had greater hypotensive and tachycardiac responses than those who did not show an alcohol-induced flush. The change in mean blood pressure induced by alcohol was negatively correlated with age, the baseline blood pressure, and the change in plasma norepinephrine. These results indicate that the major effect of acute alcohol intake is to lower blood pressure through systemic vasodilatation in hypertensive subjects. Ambulatory blood pressure monitoring may be useful for assessing blood pressure in habitual drinkers.
酒精和高血压：流行病学和实验考虑。
影响因子：
37.8
作者：
Wallace,RB;Lynch,CF;Pomrehn,PR;Criqui,MH;Heiss,G
通讯作者：
Heiss,G