Genetic Knowledge Among Participants in the Coriell Personalized Medicine Collaborative
Genetic Knowledge Among Participants in the Coriell Personalized Medicine Collaborative
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DOI：
10.1007/s10897-015-9883-z
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发表时间：
2016-04-01
影响因子：
1.9
通讯作者：
Christman, Michael F.
中科院分区：
文献类型：
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作者：
Schmidlen, Tara J.;Scheinfeldt, Laura;Christman, Michael F.
遗传素养是至关重要的基因组信息有效整合到医疗保健，但最近的研究已经进行了评估这一知识基础的现状。Coriell个性化医学协作（CPMC）是一项前瞻性研究，评估复杂疾病的个性化遗传风险报告和药物反应对行为和健康结果的影响，参与者通过在线门户网站完成遗传知识问卷和其他调查。采用多元线性回归方法分析遗传知识与遗传教育背景的关系。4 062名被试完成了遗传知识和遗传教育背景调查问卷。大多数年龄较大（平均年龄：白人（90%），女性（59%），受过高等教育（69%为学士或更高），家庭年收入超过10万美元（49%）。平均正确率为76%。控制人口统计数据显示，医疗保健提供者，先前接触过遗传学的参与者以及自我评价知识“优于大多数”的参与者更有可能获得更高的知识得分（p < 0.001）。总体而言，遗传知识是高与以前的遗传教育经验预测较高的遗传知识得分。教育有可能提高遗传知识，这是在个性化医疗中扩大使用基因组学的重要组成部分。
Genetic literacy is essential for the effective integration of genomic information into healthcare; yet few recent studies have been conducted to assess the current state of this knowledge base. Participants in the Coriell Personalized Medicine Collaborative (CPMC), a prospective study assessing the impact of personalized genetic risk reports for complex diseases and drug response on behavior and health outcomes, completed genetic knowledge questionnaires and other surveys through an online portal. To assess the association between genetic knowledge and genetic education background, multivariate linear regression was performed. 4 062 participants completed a genetic knowledge and genetic education background questionnaire. Most were older (mean age: 50), Caucasian (90 %), female (59 %), highly educated (69 % bachelor's or higher), with annual household income over $100 000 (49 %). Mean percent correct was 76 %. Controlling for demographics revealed that health care providers, participants previously exposed to genetics, and participants with 'better than most' self-rated knowledge were significantly more likely to have a higher knowledge score (p < 0.001). Overall, genetic knowledge was high with previous genetic education experience predictive of higher genetic knowledge score. Education is likely to improve genetic literacy, an important component to expanded use of genomics in personalized medicine.