The presentation of Hispanic gastric cancer patients varies by location of patient ancestry.
The presentation of Hispanic gastric cancer patients varies by location of patient ancestry.
复制标题
西班牙裔胃癌患者的介绍随患者血统的位置而变化。
DOI：
10.1002/jso.26609
复制
发表时间：
2021-12
影响因子：
2.5
通讯作者：
Wang SC
中科院分区：
文献类型：
--
作者：
Karalis JD;Ju MR;Mansour JC;Polanco PM;Yopp AC;Zeh HJ 3rd;Porembka MR;Wang SC
胃癌的临床表现在种族和民族之间有所不同。虽然在历史上被作为一个单一的群体进行研究，但西班牙裔种族是由具有相当大的生物、社会经济和文化变异性的异质群体组成的；因此，西班牙裔胃癌患者之间的组内差异在过去的研究中可能被忽略了。我们对国家癌症数据库(NCDB)进行了回顾性回顾，以比较2004-2015年间根据NCDB报告的患者祖先所在位置诊断出的拉美裔患者和胃腺癌患者。我们确定了3811名患者的队列。在墨西哥和南美/中美洲血统的患者中，女性、发病较早的患者和IV期疾病的比例较高。此外，墨西哥患者(15%)和南美/中美洲患者(11%)在40岁之前确诊的比例明显高于古巴人(2%)、DR患者(6%)和PR患者(3%；p<；0.0001)。墨西哥血统与5年全因死亡率增加34%独立相关(HR 1.34；95%CI 1.09-1.64)。拉美裔胃癌患者的临床和流行病学因血统不同而有显著差异。未来的数据收集工作应该努力捕捉拉美裔族群固有的这种细粒度。
The clinical presentation of gastric cancer varies between racial and ethnic groups. While historically studied as a monolithic population, the Hispanic ethnicity is comprised of heterogenous groups with considerable biologic, socioeconomic, and cultural variability; therefore, intra-group differences among Hispanic gastric cancer patients may have been overlooked in past research. We conducted a retrospective review of the National Cancer Database (NCDB) to compare Hispanic patients with gastric adenocarcinoma diagnosed between 2004–2015, by NCDB-reported location of patient ancestry. We identified a cohort of 3811 patients. There were higher proportions of females, patients with early disease onset, and stage IV disease among patients of Mexican and South/Central American ancestry. Additionally, a significantly larger proportion of Mexican (15%) and South/Central American patients (11%) were diagnosed before age 40, in contrast to Cubans (2%), DR (6%), and PR (3%; p< 0.0001). Mexican ancestry was independently associated with a 34% increased rate of all-cause mortality at 5 years (HR 1.34; 95% CI 1.09–1.64). Significant clinical and epidemiological differences exist among Hispanic gastric cancer patients based on location of ancestry. Future data collection endeavors should strive to capture this granularity inherent to the Hispanic ethnicity.
登录
查看更多内容
影响因子：
3.8
作者：
Huang, Robert J.;Sharp, Nora;Palaniappan, Latha P.
通讯作者：
Palaniappan, Latha P.
影响因子：
6.2
作者：
Al-Refaie, Waddah B.;Tseng, Jennifer F.;Feig, Barry W.
通讯作者：
Feig, Barry W.
影响因子：
2.5
作者：
Zhao, Beiqun;Leichman, Lawrence P.;Kelly, Kaitlyn J.
通讯作者：
Kelly, Kaitlyn J.
DOI：
10.1073/pnas.0914618107
发表时间：
2010-05-11
影响因子：
11.1
作者：
Bryc, Katarzyna;Velez, Christopher;Ostrer, Harry
通讯作者：
Ostrer, Harry
影响因子：
2.3
作者：
Klapheke, Amy K.;Carvajal-Carmona, Luis G.;Cress, Rosemary D.
通讯作者：
Cress, Rosemary D.