TNF-α and insulin resistance:: Summary and future prospects
TNF-α and insulin resistance:: Summary and future prospects
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DOI：
10.1023/a:1006865715292
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发表时间：
1998-05-01
影响因子：
4.3
通讯作者：
Spiegelman, B
中科院分区：
文献类型：
--
作者：
Peraldi, P;Spiegelman, B
虽然肥胖的原因仍然难以捉摸，但肥胖和胰岛素抵抗之间的关系是一个公认的事实[1]。胰岛素抵抗（Insulin resistance，IR）是指对一定剂量胰岛素的反应小于正常水平，导致肥胖患者出现高脂血症、动脉硬化和高血压等多种病理问题。一些证据表明，细胞因子肿瘤坏死因子α（TNF-α）是肥胖期间观察到的胰岛素抵抗状态的重要参与者。在这篇综述中，我们将试图总结什么是已知的TNF-α在肥胖期间胰岛素抵抗的功能，以及TNF-α如何干扰胰岛素信号。
While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-alpha) is an important player in the state of insulin resistance observed during obesity. In this review we will try to summarize what is known about the function of TNF-alpha in insulin resistance during obesity and how TNF-alpha interferes with insulin signaling.