Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future perspectives.
Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future perspectives.
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DOI：
10.1007/s00259-020-04843-6
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发表时间：
2021-01
影响因子：
9.1
通讯作者：
Sachpekidis C
中科院分区：
文献类型：
--
作者：
Dimitrakopoulou-Strauss A;Pan L;Sachpekidis C
到目前为止，动态正电子发射计算机断层扫描(DPET)研究主要用于研究目的。虽然人们普遍认为dPET提供的信息优于常规的静态PET采集，但动态方案的持续时间、用于动态测量的当代临床PET系统覆盖相对较小的人体轴向范围(FOV)以及数据评估的复杂性阻碍了其在临床常规应用中的实施。然而，新一代具有扩展视野的PET/CT扫描仪的开发，以及提供更好的分割算法、动脉输入功能的自动检索和参数成像的自动计算的更复杂的评估软件包的开发，与专用的较短的动态方案相结合，将促进dPET的更广泛使用。预计这将有助于肿瘤学诊断和治疗评估。本综述的目的是通过动力学建模、基于隔室和非隔室方法以及参数成像，介绍在肿瘤学中关于dPET分析的一些一般性考虑。此外，还概述了该方法的临床应用现状和前景。
Dynamic PET (dPET) studies have been used until now primarily within research purposes. Although it is generally accepted that the information provided by dPET is superior to that of conventional static PET acquisitions acquired usually 60 min post injection of the radiotracer, the duration of dynamic protocols, the limited axial field of view (FOV) of current generation clinical PET systems covering a relatively small axial extent of the human body for a dynamic measurement, and the complexity of data evaluation have hampered its implementation into clinical routine. However, the development of new-generation PET/CT scanners with an extended FOV as well as of more sophisticated evaluation software packages that offer better segmentation algorithms, automatic retrieval of the arterial input function, and automatic calculation of parametric imaging, in combination with dedicated shorter dynamic protocols, will facilitate the wider use of dPET. This is expected to aid in oncological diagnostics and therapy assessment. The aim of this review is to present some general considerations about dPET analysis in oncology by means of kinetic modeling, based on compartmental and noncompartmental approaches, and parametric imaging. Moreover, the current clinical applications and future perspectives of the modality are outlined.
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DOI：
10.1102/1470-7330.2012.0033
发表时间：
2012-09-28
期刊：
Cancer imaging : the official publication of the International Cancer Imaging Society
影响因子：
--
作者：
Dimitrakopoulou-Strauss A;Pan L;Strauss LG
通讯作者：
Strauss LG
DOI：
10.1097/00004647-199802000-00005
发表时间：
1998-02-01
影响因子：
6.3
作者：
Hasselbalch, SG;Madsen, PL;Paulson, OB
通讯作者：
Paulson, OB
影响因子：
9.3
作者：
Dimitrakopoulou-Strauss, Antonia;Hohenberger, Peter;Strauss, Ludwig G.
通讯作者：
Strauss, Ludwig G.
影响因子：
10.6
作者：
Dimitrakopoulou-Strauss, Antonia;Hoffmann, Martin;Strauss, Ludwig G.
通讯作者：
Strauss, Ludwig G.
影响因子：
10.6
作者：
Dimitrakopoulou-Strauss, Antonia;Hohenberger, Peter;Strauss, Ludwig G.
通讯作者：
Strauss, Ludwig G.