Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer
Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer
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DOI：
10.21873/anticanres.11298
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发表时间：
2017-01-01
影响因子：
2
通讯作者：
Hur, Hoon
中科院分区：
文献类型：
--
作者：
Lee, Dakeun;Yu, Eun Ji;Hur, Hoon
背景：癌胚 mRNA 结合蛋白、人胰岛素样生长因子 II mRNA 结合蛋白 3 (IMP3) 在胃癌 (GC) 中的临床病理意义尚不完全清楚。材料和方法：使用 346 名 GC 患者的标本构建组织微阵列块，以评估 IMP3 表达在 GC 中的临床病理学作用。这些结果通过 Kaplan-Meier 绘图仪的 876 名患者的在线数据集进行了验证。收集 15 名对照者和 57 名 GC 患者的血清，以比较组间血清 IMP3 水平。结果：IMP3的高表达与不良预后显着相关。 Kaplan-Meier 绘图仪的生存曲线显示，IMP3 高表达与较差的无病生存率和总生存率显着相关。结论：IMP3 的组织过度表达可作为晚期疾病或淋巴结转移的预测因子，并且与 GC 的较差预后相关。
Background: The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood. Materials and Methods: Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups. Results: High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival. Conclusion: Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs.