Clinical characteristics of delayed endolymphatic hydrops in Japan: A nationwide survey by the Peripheral Vestibular Disorder Research Committee of Japan
Clinical characteristics of delayed endolymphatic hydrops in Japan: A nationwide survey by the Peripheral Vestibular Disorder Research Committee of Japan
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DOI：
10.3109/00016481003745543
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发表时间：
2010-10-01
影响因子：
1.4
通讯作者：
Naganuma, Hideaki
中科院分区：
文献类型：
--
作者：
Shojaku, Hideo;Watanabe, Yukio;Naganuma, Hideaki
结论：与几乎所有既往有突发性耳聋和流行性腮腺炎性耳聋的迟发性内淋巴积水 (DEH) 病例类似，三分之二的既往有不明原因耳聋且在儿童早期发病的 DEH 病例在既往耳聋后 40 年内出现 DEH 症状。尽管诊断出先例耳聋，但在大多数 DEH 病例中，病毒性迷路炎可能会导致晚期内淋巴积水，长达 40 年。目的：明确日本DEH的特点。方法：通过日本周围前庭疾病研究委员会进行的全国性多中心调查收集了 198 例 DEH 病例的临床信息。结果：同侧型DEH的发生率为47.5%，与对侧型DEH的发生率基本相当。在这两种类型的 DEH 中，最常见的既往耳聋诊断是在儿童早期发病的原因不明的耳聋：在这两种类型的 DEH 中，该比例为 43.9%。突发性耳聋和腮腺炎耳聋是继发性耳聋的后续诊断。儿童早期发病的不明原因耳聋与 DEH 之间的发病时间延迟分布与突发性腮腺炎性耳聋与 DEH 之间的分布不同。
Conclusion: Similarly to almost all delayed endolymphatic hydrops (DEH) cases with both precedent sudden deafness and mumps deafness, two-thirds of DEH cases with precedent deafness of unknown cause with onset in early childhood developed DEH symptoms within 40 years after the precedent deafness. In spite of the diagnosis of precedent deafness, viral labyrinthitis may build up the late endolymphatic hydrops in most DEH cases up to four decades. Objective: To clarify the characteristics of DEH in Japan. Methods: Clinical information on 198 DEH cases was collected by nationwide, multicenter surveys conducted by the Peripheral Vestibular Disorders Research Committee of Japan. Results: The incidence of the ipsilateral type of DEH was 47.5%, which was almost equal to that of the contralateral type. In both types of DEH, the most common diagnosis of precedent deafness was deafness of unknown cause with onset in early childhood: 43.9% in both types of DEH. Sudden deafness and mumps deafness were the subsequent diagnoses of precedent deafness. The distribution of time delay of the onset between precedent deafness of unknown cause with onset in early childhood and DEH was different from that between precedent sudden and mumps deafness and DEH.