Tianjin Gestational Diabetes Mellitus Prevention Program Study design, methods, and 1-year interim report on the feasibility of lifestyle intervention program
Tianjin Gestational Diabetes Mellitus Prevention Program Study design, methods, and 1-year interim report on the feasibility of lifestyle intervention program
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DOI：
10.1016/j.diabres.2012.09.015
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发表时间：
2012-12-01
影响因子：
5.1
通讯作者：
Tuomilehto, Jaakko
中科院分区：
文献类型：
--
作者：
Hu, Gang;Tian, Huiguang;Tuomilehto, Jaakko
目的：评估生活方式干预是否能降低天津市妊娠期糖尿病（GDM）预防项目中既往有GDM的妇女2型糖尿病的风险。方法：从2005年到2009年，1180名确诊为GDM的女性被随机分为生活方式干预组（n = 586）和对照组（n = 594）。干预的主要内容包括第一年与研究营养师进行六次面对面的会议，第二年进行两次额外的会议和两次电话会议。结果：第一年，干预组404名受试者的平均体重下降1.40 kg(2.1%)，对照组为0.21 kg (0.3%) (P = 0.001)，基线超重女性（体重指数[BMI] >= 24 kg/m(2)）干预组（2.91 kg/4.2%）比对照组（0.51 kg/0.7%）下降更为显著（P < 0.001）。此外，与对照组相比，干预组女性的身体质量指数、体脂、腰围和血浆胰岛素水平都有所下降，行为也有所改善，包括闲暇时间活动和膳食纤维摄入量增加，久坐时间和脂肪消耗减少。结论：中期结果支持生活方式干预方案的有效性和可行性。爱思唯尔爱尔兰有限公司版权所有。版权所有。
Objective: To assess whether lifestyle intervention can reduce type 2 diabetes risk in women with prior GDM in the Tianjin Gestational Diabetes Mellitus (GDM) Prevention Program.Methods: 1180 women who were diagnosed with GDM from 2005 to 2009 were randomly assigned to either a lifestyle intervention (n = 586) or a control group (n = 594). Major elements of the intervention include six face-to-face meetings with study dietitians in the first year, and two additional sessions and two telephone calls in second year.Results: During the first year, average body weight loss in the first 404 subjects was 1.40 kg (2.1%) in the intervention group vs 0.21 kg (0.3%) in the control group (P = 0.001), and the decrease was more significant among baseline overweight women (body bass index [BMI] >= 24 kg/m(2)) in the intervention (2.91 kg/4.2%) compared with that in the control group (0.51 kg/0.7%) (P < 0.001). In addition, women in the intervention group, compared with those in the control group, have decreased BMI, body fat, waist circumference, and plasma insulin levels, and have improved behaviors including increased leisure time activity and dietary fiber intake and decreased sedentary time and fat consumptions.Conclusion: The interim results support the efficacy and feasibility of the lifestyle intervention program. Crown Copyright (C) 2012 Published by Elsevier Ireland Ltd. All rights reserved.