Weak evidence of bright light effects on human LH and FSH.
Weak evidence of bright light effects on human LH and FSH.
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DOI：
10.1186/1740-3391-8-5
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发表时间：
2010-05-11
影响因子：
--
通讯作者：
Rex KM
中科院分区：
文献类型：
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作者：
Kripke DF;Elliott JA;Youngstedt SD;Parry BL;Hauger RL;Rex KM
大多数哺乳动物都是季节性繁殖动物，它们的性腺会在春季和夏季生长，以备繁殖。随着白昼长度的增加，两种促性腺激素——促黄体生成素（LH）和促卵泡激素（FSH）的分泌增加。这种反应很大程度上是由光控制的。光对促性腺激素的影响是通过对视交叉上核的影响和昼夜节律系统的反应介导的。有证据表明，人类的季节性繁殖受到类似机制的调节，光线刺激黄体生成素分泌，但灵长类动物的反应似乎很复杂。为了进一步了解强光对人体黄体生成素和卵泡刺激素分泌的影响，我们分析了为其他目的进行的三个实验中收集的尿液样本。首先，年龄在18-30岁和60-75岁的志愿者开始了一个超短的90分钟睡眠-觉醒周期，在此期间，他们在每天的平衡时间暴露在3000勒克斯的光下3小时，重复3天。检测尿液样本以探索任何LH相反应曲线。其次，60-79岁的抑郁参与者在明亮的灯光或暗淡的安慰剂灯光下治疗28天，并在治疗前后测量尿LH和FSH。第三，年龄在20-45岁的经前烦躁不安（PMDD）女性接受一次3小时的晨光照射，在治疗前后测量尿液中的LH和FSH。三项研究中有两项显示光照治疗后LH显著增加，FSH也有增加的趋势，但与平行安慰剂治疗没有显著对比，也没有显著的日间治疗效果。这些结果为强光可能增加黄体生成素分泌的假设提供了一些支持。可能需要更长期的研究来阐明光对人体黄体生成素和卵泡刺激素的影响。
Most mammals are seasonal breeders whose gonads grow to anticipate reproduction in the spring and summer. As day length increases, secretion increases for two gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH). This response is largely controlled by light. Light effects on gonadotropins are mediated through effects on the suprachiasmatic nucleus and responses of the circadian system. There is some evidence that seasonal breeding in humans is regulated by similar mechanisms, and that light stimulates LH secretion, but primate responses seem complex. To gain further information on effects of bright light on LH and FSH secretion in humans, we analyzed urine samples collected in three experiments conducted for other goals. First, volunteers ages 18-30 years and 60-75 commenced an ultra-short 90-min sleep-wake cycle, during which they were exposed to 3000 lux light for 3 hours at balanced times of day, repeated for 3 days. Urine samples were assayed to explore any LH phase response curve. Second, depressed participants 60-79 years of age were treated with bright light or dim placebo light for 28 days, with measurements of urinary LH and FSH before and after treatment. Third, women of ages 20-45 years with premenstrual dysphoric disorder (PMDD) were treated to one 3-hour exposure of morning light, measuring LH and FSH in urine before and after the treatments. Two of the three studies showed significant increases in LH after light treatment, and FSH also tended to increase, but there were no significant contrasts with parallel placebo treatments and no significant time-of-day treatment effects. These results gave some support for the hypothesis that bright light may augment LH secretion. Longer-duration studies may be needed to clarify the effects of light on human LH and FSH.