Protein kinases and phosphatases in the control of cell fate.
Protein kinases and phosphatases in the control of cell fate.
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DOI：
10.4061/2011/329098
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Pinton P
中科院分区：
文献类型：
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作者：
Bononi A;Agnoletto C;De Marchi E;Marchi S;Patergnani S;Bonora M;Giorgi C;Missiroli S;Poletti F;Rimessi A;Pinton P
蛋白质磷酸化控制着细胞命运的许多方面，在病理条件下经常被解除调控。最近的几个发现提供了一个有趣的洞察力，揭示了不同亚细胞间蛋白质磷酸化的空间调节，以及如何通过特定的激酶和磷酸酶来精细地协调这一过程。本文将重点介绍(I)磷脂酰肌醇3-激酶(PI3K)途径，特别是Akt和mTOR，以及磷酸酶PP2A和PTEN，以及(Ii)丝氨酸/苏氨酸激酶的PKC家族。我们将研究由这些激酶和磷酸酶控制的细胞生理学的一般方面，重点介绍驱动细胞分裂、增殖和凋亡的信号通路。
Protein phosphorylation controls many aspects of cell fate and is often deregulated in pathological conditions. Several recent findings have provided an intriguing insight into the spatial regulation of protein phosphorylation across different subcellular compartments and how this can be finely orchestrated by specific kinases and phosphatases. In this review, the focus will be placed on (i) the phosphoinositide 3-kinase (PI3K) pathway, specifically on the kinases Akt and mTOR and on the phosphatases PP2a and PTEN, and on (ii) the PKC family of serine/threonine kinases. We will look at general aspects of cell physiology controlled by these kinases and phosphatases, highlighting the signalling pathways that drive cell division, proliferation, and apoptosis.