Is action potential threshold lowest in the axon?
Is action potential threshold lowest in the axon?
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DOI：
10.1038/nn.2203
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发表时间：
2008-11-01
影响因子：
25
通讯作者：
Stuart, Greg J.
中科院分区：
文献类型：
--
作者：
Kole, Maarten H. P.;Stuart, Greg J.
动作电位阈值被认为是最低的轴突，但当使用传统的技术进行测量时，我们发现，大鼠皮层锥体神经元的动作电位电压阈值高于在轴突比在其他神经元的位置。与此相反，无论是电流阈值和电压阈值的孤立体-树突棘在索马高得多。这些数据表明，动作电位阈值确实是最低的轴突。
Action potential threshold is thought to be lowest in the axon, but when measured using conventional techniques, we found that action potential voltage threshold of rat cortical pyramidal neurons was higher in the axon than at other neuronal locations. In contrast, both current threshold and voltage threshold of the isolated somato-dendritic spike were substantially higher at the soma. These data indicate that action potential threshold is indeed lowest in the axon.