Neuroprotective mechanisms of the ACE2-angiotensin-(1-7)-Mas axis in stroke.
Neuroprotective mechanisms of the ACE2-angiotensin-(1-7)-Mas axis in stroke.
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DOI：
10.1007/s11906-014-0512-2
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发表时间：
2015-02
影响因子：
5.6
通讯作者：
Sumners, Colin
中科院分区：
文献类型：
--
作者：
Bennion, Douglas M.;Haltigan, Emily;Regenhardt, Robert W.;Steckelings, U. Muscha;Sumners, Colin
关键词：
The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2–angiotensin-(1-7)–Mas axis [ACE2–Ang-(1-7)–Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective role of the ACE2–Ang-(1-7)–Mas axis in stroke, along with a focused discussion on the potential mechanisms of neuroprotective effects of Ang-(1-7) in stroke. The latter incorporates evidence describing the actions of Ang-(1-7) to counter the deleterious effects of angiotensin II (AngII) via its type 1 receptor, including anti-inflammatory, anti-oxidant, vasodilatory, and angiogenic effects, and the role of altered kinase–phosphatase signaling. Interactions of Mas with other receptors, including bradykinin receptors and AngII type 2 receptors are also considered. A more complete understanding of the mechanisms of action of Ang-(1-7) to elicit neuroprotection will serve as an essential step toward research into potential targeted therapeutics in the clinical setting.
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10.1152/ajprenal.00278.2010
发表时间：
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影响因子：
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