Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine?
Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine?
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DOI：
10.3945/ajcn.110.006502
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发表时间：
2011-01-01
影响因子：
7.1
通讯作者：
Baylin, Ana
中科院分区：
文献类型：
--
作者：
Gong, Jian;Campos, Hannia;Baylin, Ana
背景资料：动物模型表明，脂肪来源的棕榈油酸可能作为一种脂因子，有助于抵抗饮食诱导的肥胖。人类研究仅评估了血浆棕榈油酸浓度，这反映了肝脏中硬脂酰辅酶A去饱和酶1（SCD 1）的活性，并与肥胖风险增加有关。棕榈油酸的这些明显相反的作用值得在人类中进一步研究。由于碳水化合物的摄入可以增加肝脏SCD 1的活性，它可以作为一个分层变量，以解开脂肪组织SCD 1的影响相比，肝脏SCD 1的活性对obesity.Objective的影响：我们研究了脂肪组织棕榈油酸和SCD 1的活性是否与肥胖患病率下降，以及这种关联是否被碳水化合物的摄入修改。设计：对哥斯达黎加的1926名成年人进行了一项横断面研究，检查了肥胖[体重指数（kg/m2）>30]的患病率（PR）。两个去饱和指数（16：1/16：0和18：1/18：0）被用作脂肪组织SCD 1 activity.Results的替代措施：我们观察到脂肪组织棕榈油酸浓度和肥胖之间的正相关（棕榈油酸最低与最高五分位数的PR：2.27; 95%CI：1.52，3.38;趋势P < 0.0001）。肥胖和脂肪去饱和指数之间也有显著的相关性。脂肪组织棕榈油酸浓度和肥胖之间的关联被削弱的人与低碳水化合物intake.Conclusions：有没有直接的证据表明，脂肪组织棕榈油酸的行为作为一种脂因子，以减少人类肥胖的发生。然而，低碳水化合物摄入对这种关联的减弱需要进一步研究脂肪衍生的棕榈油酸和肥胖风险。美国临床营养杂志2011;93：186-91。
Background: Animal models have shown that adipose-derived palmitoleic acid may serve as a lipokine that contributes to resistance to diet-induced obesity. Studies in humans have evaluated only plasma palmitoleic acid concentrations, which reflect stearoyl-coenzyme A desaturase 1 (SCD1) activity in the liver and are associated with increased risk of obesity. These apparent opposite effects of palmitoleic acid deserve further research in humans. Because carbohydrate intake can increase hepatic SCD1 activity, it could be used as a stratifying variable to disentangle the effects of adipose tissue SCD1 compared with the effects of liver SCD1 activity on obesity.Objective: We examined whether the effects of adipose tissue palmitoleic acid and SCD1 activity were associated with decreased obesity prevalence and whether this association was modified by carbohydrate intake.Design: Prevalence ratios (PRs) of obesity [body mass index (in kg/m(2)) >30] were examined in a cross-sectional study in 1926 adults in Costa Rica. Two desaturation indexes (16:1/16:0 and 18:1/18:0) were used as surrogate measures of adipose tissue SCD1 activity.Results: We observed a positive association between adipose tissue palmitoleic acid concentrations and obesity (PR for lowest compared with highest quintiles of palmitoleic acid: 2.27; 95% CI: 1.52, 3.38; P for trend < 0.0001). A significant association was also observed between obesity and adipose desaturation indexes. The association between adipose tissue palmitoleic acid concentrations and obesity was attenuated in persons with low carbohydrate intake.Conclusions: There is no direct evidence that adipose tissue palmitoleic acid behaves as a lipokine to reduce obesity occurrence in humans. However, the attenuation of the association by low carbohydrate intake warrants further research on adipose-derived palmitoleic acid and obesity risk. Am J Clin Nutr 2011;93:186-91.