RISK-FACTORS FOR HIV INFECTION IN MALE SEXUAL CONTACTS OF MEN WITH AIDS OR AN AIDS-RELATED CONDITION
RISK-FACTORS FOR HIV INFECTION IN MALE SEXUAL CONTACTS OF MEN WITH AIDS OR AN AIDS-RELATED CONDITION
复制标题
DOI：
10.1093/oxfordjournals.aje.a115026
复制
发表时间：
1988-10-01
影响因子：
5
通讯作者：
SOSKOLNE, CL
中科院分区：
文献类型：
--
作者：
COATES, RA;CALZAVARA, LM;SOSKOLNE, CL
1984年7月至1985年7月，在加拿大多伦多进行了一项前瞻性研究，共招募了246名与获得性免疫缺陷综合征（AIDS）或AIDS相关疾病男性有性接触的健康男性。在诱导时，收集有关接触者与其主要病例之间的性关系、与其他男性的性活动、性传播疾病和其他疾病史以及娱乐性药物使用的数据。在招募时，144名性接触者有人体免疫缺陷病毒（艾滋病毒）抗体; 102名接触者在入职时和招募后三个月血清反应阴性。艾滋病毒血清阳性和性伴侣总数之间没有关联可以证明。在单变量和多变量分析中，接受性和插入性以及与原发病例的性交，以及表明或可能导致肛门直肠粘膜损伤的活动（直肠冲洗，肛周出血，在肛门接受对象，以及接受性拳交）与HIV血清阳性密切相关。在最终的多元Logistic回归模型中，观察到两个显着的相互作用效应：接受性肛交和插入性肛交之间的相互作用，以及接受性肛交和肛门直肠粘膜损伤指数之间的相互作用。这两个相互作用项具有负回归系数，这表明在一种性活动中的改变不会在另一种活动中没有类似的修改的情况下降低HIV感染的风险。口腔-生殖器性接触和口腔-肛门性接触之间没有关联，当调整接受性肛交的频率时，这些性活动的比值比下降到低于1.0的水平。
A total of 246 healthy male sexual contacts of men with either acquired immunodeficiency syndrome (AIDS) or an AIDS-related condition were recruited into a prospective study in Toronto, Canada between July 1984 and July 1985. At induction, data were collected on the sexual relationship between the contact and his primary case, sexual activities with other men, history of sexually transmitted diseases and other diseases, and use of recreational drugs. At recruitment, 144 sexual contacts had antibodies to human immunodeficiency virus (HIV); 102 of the contacts were seronegative at induction and at three months following recruitment. No association between HIV seropositivity and total number of sexual partners could be demonstrated. In univariate and multivariate analyses, receptive and insertive and intercourse with the primary cases, and activities which either indicated or potentially caused anorectal mucosal injury (rectal douching, perianal bleeding, receipt of objects in ano, and receptive fisting) were strongly associated with HIV seropositivity. In the final multiple logistic regression model, two significant interaction effects were observed: the interaction between receptive anal intercourse and insertive anal intercourse and that between receptive anal intercourse and the anorectal mucosal injury index. These two interaction terms had negative regression coefficients which suggested that change in one sexual activity would not decrementally reduce risk of HIV infection without a comparable modification in the other activity. No association could be demonstrated between oral-genital and oral-anal sexual contact and odds ratios for these sexual activities declined to levels below 1.0 when adjusted for frequency of receptive anal intercourse.