Controlled delivery of peptides and proteins.
Controlled delivery of peptides and proteins.
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DOI：
10.2174/138161207779313795
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发表时间：
2007
影响因子：
3.1
通讯作者：
I. Degim;N. Çelebi
中科院分区：
文献类型：
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作者：
I. Degim;N. Çelebi
制药科学的最终目的/目标是设计成功的剂型进行有效治疗，考虑个体患者的需求和依从性。开发新的药物实体，特别是使用肽和蛋白质，越来越重要，并吸引了越来越多的兴趣，因为它们在低剂量下特别有效。由于生物技术和制药应用的知识和进步，这些非常有效和特异的肽和蛋白质现在可以大量生产。现在市场上有许多肽和蛋白质产品，并且文献中已经发表了许多研究它们的研究。尽管许多肽/蛋白质类产品通常设计用于肠胃外给药，但也使用了一些其他非侵入性途径。例如，去氨加压素经鼻递送，脱氧核糖核酸酶通过吸入递送。虽然肽和蛋白质通常是口服无活性的，但环孢素是个例外。为了设计和开发长效、更有效的肽/蛋白质药物，需要了解和阐明控释机制和有效参数。本文综述了各种肽/蛋白质给药系统，包括生物可降解和不可降解的微球、微囊、纳米胶囊、可注射植入剂、扩散控制水凝胶和其他亲水系统、微乳和多重乳液以及离子导入或电穿孔的应用，并讨论了最新的研究结果。
The final aim/target of Pharmaceutical Sciences is to design successful dosage forms for effective therapy, considering individual patient needs and compliance. Development of new drug entities, particularly using peptides and proteins, is growing in importance and attracting increased interest, as they are specifically effective at a comparably low dose. These very potent and specific peptides and proteins can now be produced in large quantities due to increased knowledge and advancements in biotechnological and pharmaceutical applications. A number of peptide and protein products are now available on the market, and numerous studies investigating them have been published in the literature. Although many peptide/protein like products are generally designed for parenteral administration, some other noninvasive routes have also been used. For example, desmopressin is delivered nasally and deoxyribonuclease by inhalation. Although peptides and proteins are generally orally inactive, cyclosporine is an exception. In order to design and develop long-acting, more effective peptide/protein drugs, the controlled release mechanisms and effective parameters need to be understood and clarified. Therefore, we review herein various peptide/protein delivery systems, including biodegradable and nondegradable microspheres, microcapsules, nanocapsules, injectable implants, diffusion-controlled hydrogels and other hydrophilic systems, microemulsions and multiple emulsions, and the use of iontophoresis or electroporation, and discuss the results of recent researches.