Haemodynamic changes induced by submaximal isometric contraction in painful and non-painful human masseter using near-infra-red spectroscopy
Haemodynamic changes induced by submaximal isometric contraction in painful and non-painful human masseter using near-infra-red spectroscopy
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DOI：
10.1016/0003-9969(96)00009-x
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发表时间：
1996-06-01
影响因子：
3
通讯作者：
Clark, GT
中科院分区：
文献类型：
--
作者：
Delcanho, RE;Kim, YJ;Clark, GT
虽然慢性肌肉疼痛的机制知之甚少，一个流行的理论是，这是由于，部分，局部缺氧。本研究的目的是评估这一理论，使用非侵入性近红外光谱监测肌内血红蛋白（Hb）浓度和氧饱和度水平的相对变化。在三次等长30秒试验中和之后，收集了人类咬肌50%最大随意收缩的数据。10名女性，有慢性肌肉疼痛的历史，在下巴，和8个匹配的健康女性没有肌肉疼痛（对照组）参加。结果表明，咬肌收缩开始后，肌内血红蛋白浓度迅速降低，伴随着氧饱和度水平的降低。停止收缩后，Hb浓度迅速增加，然后下降到基线。对于肌肉疼痛组和对照组，在第一次试验和随后的两次试验之间发现氧饱和度的恢复曲线存在显著差异。仅观察第一次试验，并在分析中调整身高，体重和咬合力的协变量，发现两组之间存在轻微的收缩后差异，慢性肌肉疼痛组在恢复期间的氧饱和度水平较低。在Hb浓度方面发现了显著的组间差异，但没有任何显著的试验效应。这可能是众所周知的肌肉内血液的变化，如何发生在人体肌肉收缩期间和之后，反映在这些改变的相对血红蛋白浓度。慢性肌肉疼痛组在收缩后恢复期的Hb浓度变化幅度明显降低。结果支持慢性肌肉疼痛患者在持续等长收缩后的恢复期肌内再灌注较慢的概念。版权所有（C）1996 Elsevier Science Ltd.
Although mechanisms underlying chronic muscle pain are poorly understood, one prevalent theory is that it is due, in part, to localized hypoxia. The purpose of this study was to evaluate this theory using non-invasive near-infra-red spectroscopy that monitors relative changes in intramuscular haemoglobin (Hb) concentration and oxygen saturation levels. Data were collected for the human masseter muscle during and following three isometric 30-s trials al 50% maximum voluntary contraction. Ten females, with a history of chronic muscle pain in the jaw, and eight matched healthy females without muscle pain (controls) participated. Results showed that, upon initiation of masseter muscle contraction, there was a rapid reduction in the intramuscular Hb concentration concomitant with a reduction in oxygen saturation levels. After cessation of the contraction, the Hb concentration increased rapidly and then fell toward the baseline. Significant differences in the recovery profile for oxygen saturation were found between the first trial and the following two trials for both the muscle pain- and control group. Looking at the first trial only, and adjusting for covariates of height, weight and bite-force in the analysis, revealed a marginally significant postcontraction difference between the two groups with a lower level of oxygen saturation during recovery in the group with chronic muscle pain. Significant group differences were found in Hb concentrations without any significant trial effect. It is likely that the well-known changes in intramuscular blood how that occur during and after contraction in human muscles are reflected in these altered relative Hb concentrations. The group with chronic muscle pain showed a clearly reduced magnitude of the Hb concentration change in the postcontraction recovery period. The results support the concept that patients with chronic muscle pain have a slower intramuscular reperfusion during the recovery phase after sustained isometric contractions. Copyright (C) 1996 Elsevier Science Ltd.