High-frequency ultrasonic atomization for drug delivery to rodent animal models - optimal particle size for lung inhalation of difluoromethyl ornithine.
High-frequency ultrasonic atomization for drug delivery to rodent animal models - optimal particle size for lung inhalation of difluoromethyl ornithine.
复制标题
用于向啮齿动物模型输送药物的高频超声雾化 - 二氟甲基鸟氨酸肺部吸入的最佳粒径。
DOI：
10.1080/01902140802022484
复制
发表时间：
2008
影响因子：
1.7
通讯作者：
Wiedmann,TimothyScott
中科院分区：
文献类型：
--
作者：
Zhang,Guifang;Fandrey,Chris;Naqwi,Amir;Wiedmann,TimothyScott
比较了高频率 (8 MHz) 和低频率 (1.7 MHz) 超声波换能器向小鼠肺部输送气溶胶的情况。两个传感器的气溶胶浓度（干颗粒质量/空气体积）随着二氟甲基鸟氨酸溶液浓度呈非线性上升。粒径与溶液浓度的立方根成线性关系，低频换能器的斜率比高频换能器的斜率大8倍。发现通过肺中测定的质量相对于计算的吸入质量评估的沉积分数随颗粒尺寸呈指数下降。尽管沉积分数较低，低频换能器提供了更高的剂量，但高频换能器效率更高，并且在下呼吸道中提供更具选择性的沉积，同时对气溶胶干燥的要求显着降低。
A high-(8-MHz) and a low-(1.7-MHz) frequency ultrasonic transducer were compared for delivering aerosols to mouse lung. The aerosol concentration (mass of dry particles/volume of air) rose nonlinearly with solution concentration of difluoromethyl ornithine for both transducers. The particle size was linear with the cube root of the solution concentration, and the slope of the low-frequency transducer was 8 times greater than that of the high-frequency transducer. The deposition fraction assessed by the assayed mass in the lung relative to the calculated inhaled mass was found to decline exponentially with particle size. The lower-frequency transducer provided a higher dose despite a lower deposition fraction, but the high-frequency transducer was more efficient and provides a more selective deposition in the lower respiratory tract while operating with significantly less demands on aerosol drying.