EFFECTS OF TOLUENE ON METABOLISM, DISPOSITION AND HEMATOPOIETIC TOXICITY OF [BENZENE-H-3
EFFECTS OF TOLUENE ON METABOLISM, DISPOSITION AND HEMATOPOIETIC TOXICITY OF [BENZENE-H-3
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DOI：
10.1016/0006-2952(77)90180-0
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发表时间：
1977-01-01
影响因子：
5.8
通讯作者：
SNYDER, R
中科院分区：
文献类型：
--
作者：
ANDREWS, LS;LEE, EW;SNYDER, R
[苯是化学工业中使用最广泛的芳烃。] [~ 3 H]苯染毒小鼠后，~（59）Fe掺入红细胞的量减少，苯及其代谢产物在骨髓和其它组织中蓄积。甲苯保护对苯诱导的抑郁症的红细胞59铁的摄取，并降低苯代谢物在骨髓中的水平，而不影响苯在这个组织中的水平。甲苯可能通过抑制苯代谢发挥其保护作用，苯的代谢产物可能介导苯的造血毒性。
[Benzene is the most extensively used aromatic hydrocarbon in chemical industry.] The administration of [3H]benzene to mice resulted in the decreased incorporation of 59Fe into red cells and the accumulation of benzene and its metabolites in bone marrow and other tissues. Toluene protected against the benzene-induced depression of red cell 59Fe uptake and reduced the levels of benzene metabolites in bone marrow without affecting the level of benzene in this tissue. Toluene probably exerted its protective effect by inhibiting benzene metabolism and a metabolite of benzene probably mediates the observed hemopoietic toxicity of benzene.