Physiology Considerations in Geriatric Patients.
Physiology Considerations in Geriatric Patients.
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DOI：
10.1016/j.anclin.2015.05.003
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发表时间：
2015-09-01
影响因子：
--
通讯作者：
Hughes, Christopher G
中科院分区：
文献类型：
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作者：
Alvis, Bret D;Hughes, Christopher G
随着人们年龄的增长，生理学在结构、功能和分子水平上发生变化，每个主要器官系统都会随着时间的推移而经历生理变化。神经系统的变化主要导致认知障碍，心血管系统血压升高，心输出量降低，呼吸系统动脉氧合血红蛋白水平降低，胃肠系统胃排空延迟和肝脏代谢减少，肾脏系统肾小球滤过率降低。这些变化结合起来造成了复杂的生理状况。对于接受全身麻醉的老年患者，必须考虑这种独特的生理学。
Physiology changes at the structural, functional, and molecular levels as people age, and every major organ system experiences physiologic change with time. The changes to the nervous system result mostly in cognitive impairments, the cardiovascular system develops higher blood pressures with lower cardiac output, the respiratory system undergoes a reduction of arterial oxyhemoglobin levels, the gastrointestinal system experiences delayed gastric emptying and reduction of hepatic metabolism, and the renal system experiences a diminished glomerular filtration rate. Combined, these changes create a complex physiologic condition. This unique physiology must be taken into consideration for geriatric patients undergoing general anesthesia.