Red Fluorescence ofEu3+-Doped ZnAl-LDH Response toIntercalation andRelease ofIbuprofen
Red Fluorescence ofEu3+-Doped ZnAl-LDH Response toIntercalation andRelease ofIbuprofen
复制标题
Eu3 掺杂 ZnAl-LDH 对布洛芬嵌入和释放的红色荧光响应
DOI：
10.1007/s10895-021-02883-1
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发表时间：
2022
影响因子：
2.7
通讯作者：
Yongxiu Li
中科院分区：
文献类型：
--
作者：
Yufeng Chen;Xingxing Qiu;Chao Li;Yajiao Zhang;Yongxiu Li
具有识别功能的给药系统具有重要的应用价值。为此，我们研究了Eu3+掺杂ZnAl-LDH的红色荧光对布洛芬（ibuprofen， IBU）嵌入和释放的响应。x射线衍射（XRD）结果表明，掺入IBU后，Eu3+掺杂ZnAl-LDH的基间距在8.85 ~ 12.04 Å之间变化。将Eu3+掺杂ZnAl-LDH在模拟肠道介质（pH为7.4、温度为37℃的磷酸盐缓冲液）中释放IBU， IBU的释放行为表现为先快速释放后缓慢释放。此外，该给药系统比其他基于ldl的给药系统具有更慢的药物释放速度。有趣的是，将IBU插入到Eu3+掺杂ZnAl-LDH中，明显降低了Eu3+掺杂ZnAl-LDH的红色荧光，而释放IBU后，红色荧光又恢复了。这种荧光反应性可能是检测IBU递送和释放的有利信号。因此，具有红色荧光的Eu3+掺杂ZnAl-LDH具有价格便宜、无毒、生物相容性好、对生物组织损伤小等优点，是具有识别功能的药物传递系统的潜在应用。
A drug delivery system with identification function is attractive and important. For this reason, the red fluorescence of Eu3+-doped ZnAl-LDH response to intercalation and release of ibuprofen (IBU) has been studied. X-ray diffraction(XRD) results showed that the basal spacing of the Eu3+-doped ZnAl-LDH varied from 8.85 to 12.04 Å after the intercalation of IBU. The release of the IBU from the Eu3+-doped ZnAl-LDH was carried out in simulated intestinal medium (phosphate buffer solutions with pH 7.4 and 37 °C), and the releasing behavior of IBU exhibited an initial rapid release followed by a slow release. Moreover, the present delivery system has slower release of drug than those of other LDH-based delivery systems. Interestingly, the intercalation of IBU into the Eu3+-doped ZnAl-LDH obviously reduced the red fluorescence of the Eu3+-doped ZnAl-LDH, whereas the red fluorescence was recovered after the release of IBU. This fluorescent responsiveness may be a favorable signal for detecting the delivery and release of IBU. Therefore, the Eu3+-doped ZnAl-LDH with red fluorescence would be potential application as drug delivery system with identification function because of its cheapness, non-toxicity, good biocompatibility, and little damage to biological tissue.