Anatomical correlates of age-related working memory declines.
Anatomical correlates of age-related working memory declines.
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DOI：
10.4061/2011/606871
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发表时间：
2011
影响因子：
4.7
通讯作者：
Little DM
中科院分区：
文献类型：
--
作者：
Schulze ET;Geary EK;Susmaras TM;Paliga JT;Maki PM;Little DM
老龄化研究一致表明，灰质体积减少和工作记忆任务表现下降之间存在关系。很少有衰老研究调查了工作记忆任务中白色物质的变化与大脑功能变化的关系。25名年轻人和25名老年人接受了解剖磁共振成像（MRI）扫描以测量灰质体积，弥散张量成像（DTI）测量各向异性分数（FA）作为白色物质完整性的测量，功能磁共振成像（fMRI）同时执行工作记忆任务。随着工作记忆负荷的增加和年龄的增加，左背侧和腹侧前额叶皮层的激活（fMRI）显著增加（年龄越大，双侧激活越大）。部分相关分析表明，即使在控制年龄，额叶FA与功能磁共振成像激活显着相关的工作记忆任务的性能。这些发现强调了白色物质完整性在正常衰老相关的工作记忆表现中的重要性。
Aging studies consistently show a relationship between decreased gray matter volume and decreased performance on working memory tasks. Few aging studies have investigated white matter changes in relation to functional brain changes during working memory tasks. Twenty-five younger and 25 older adults underwent anatomical magnetic resonance imaging (MRI) scans to measure gray matter volume, diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) as a measure of white matter integrity, and functional magnetic resonance imaging (fMRI) while performing a working memory task. Significant increases in activation (fMRI) were seen in the left dorsal and ventral lateral prefrontal cortex with increased working memory load and with increased age (older showing greater bilateral activation). Partial correlational analyses revealed that even after controlling for age, frontal FA correlated significantly with fMRI activation during performance on the working memory task. These findings highlight the importance of white matter integrity in working memory performance associated with normal aging.